Mycophenolate
Mycophenolate is an immunosupressant, first isolated in 1898 from Penicillium stoloniferum. Mycophenolate is a reversible inhibitor of inosine monophosphate dehydrogenase and thus inhibits purine synthesis, with potent cytostatic effects on both T-and B-lymphocytes. Mycophenolate is used in combination with other immunosupressants, for the treatment and prevention of graft rejection and in auto-immune or immune-mediate inflammatory disease. it was approved by the FDA in May 3, 1995, for prevention of alograft rejection. <br>Mycophenolate mofetil is the 2-morpholinoethyl ester of mycophenolic acid (MPA), belongs to a class of medications known as immunosuppressives. inosine monophosphate dehydrogenase (IMPDH) inhibitor. This medication was used originally in the management of patients with organ transplants, but is now recommended in the treatment of some autoimmune diseases.
Primary Characteristics
Mycophenolate is also known as Mycophenolate Mofetil.
It is of Synthetic origin and belongs to Mycophenolie acid.
It is classified in Immunosuppressant Agent pharmacological group.
Molecular Weight: 433.5 · Non-proprietary name: Mycophenolate.
Pharmacokinetics
Distribution: Mycophenolate has a volume of distribution is 3.8(3.6-4)l/kg. plasma protein binding is 97 %.
Elimination: plasma half-life is 16.6-17.9hr, renal excretion is <1%.
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Indications
Mycophenolate is primarily indicated in conditions like Graft rejection, Pophylaxis of acute renal transplant rejection, Pophylaxis of cardiac transplant rejection, Pophylaxis of hepatic transplant rejection, Symptoms associated with carcinoid tumours.
Contraindications
None recorded.
Dosage
Mycophenolate's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 1 g | 1 g | Every 12h | PO | Starting within 72 hrs of transplantation. |
| Paediatric Dosage (20kg) | ||||
| No data. | ||||
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Mycophenolate in overdosage may give rise to further complications which include Anemia , Anemia , Thrombocytopenia , Leucopenia, Bone marrow depression , Hyperglycemia , Hypertension , Hematuria, Tremors , Hyperglycemia, Anemia, Anemia, Disturbances of electrolyte, Disturbances of blood lipids.
Mycophenolate is known to cause more or less tolerable side effects which are usually transient. These include Alopecia, Cough , Diarrhea, dizziness, Dyspnea, GI disturbance, GI hemorrhage, Headache, Insomnia, Nausea, Pain .
Warnings / Precautions
Interference in Pathology
Mycophenolate may interfere in the diagnosis of Complete blood cell count.
Available Brands
Storage Conditions
Drug Classification
- 1.8.1 — Immunomodulators