Cephaloridine
Cephaloridine is a first generation cephalosporin antibiotic. Cephalosporins are derivatives of 7-aminocephalosporic acid and are closely related to penicillins in structure. Cephalosporins have a six membered sulfur containing ring adjoining a ß lactam ring. Cephaloridine is very active against gram positive cocci and used in a large variety of bacterial infections, such as respiratory tract, skin and urinary tract infections. Antibiotics require constant drug level in body for therapeutic effect. This is achieved by taking the medication at regular interval of time throughout the day and night as prescribed. Cephaloridine is important to take the drug for the full time period as prescribed. If you discontinue the therapy, it may result in ineffective treatment.
Primary Characteristics
It is of Semi Synthetic origin and belongs to Cephem Carboxylate.
It belongs to Peptidoglycan synthesis inhibitor pharmacological group on the basis of mechanism of action and also classified in Antibiotics pharmacological group.
Molecular Weight: 415.5 · pKa: 3.4 · Solubility in Water: 1 in 5 · Solubility in Alcohol: 1 in 1000 · Non-proprietary name: Cephaloridine.
Pharmacokinetics
Distribution: Cephaloridine has a volume of distribution is 16 litre. plasma protein binding is 20%.
Elimination: plasma half-life is 60-90 hr, renal excretion is 80%.
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Indications
Cephaloridine is primarily indicated in conditions like Bacterial infections, Bronchitis, Gonorrhoea.
Cephaloridine is also indicated for secondary conditions like Corneal ulcers, Intraocular infections.
Contraindications
Cephaloridine is contraindicated in conditions like Blood dyscrasias, Hypersensitivity to the drug.
Dosage
Cephaloridine's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 7.142 mg/kg | 7.142 mg/kg | Every 8h | IM | maximum daily dose must be limited to 4 g |
| 0.714 mg/kg | 0.714 mg/kg | — | Intra Thecal | - |
| 7.142 mg/kg | 7.142 mg/kg | Every 8h | SC | - |
| Paediatric Dosage (20kg) | ||||
| 2.5 mg/kg | 2.5 mg/kg | Every 24h | Intra Thecal | - |
| Neonatal Dosage (3kg) | ||||
| 15 mg/kg | 15 mg/kg | Every 12h | Intramuscular | |
| 1.56 mg/kg | 1.56 mg/kg | Every 24h | Intrathecal | |
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Cephaloridine in overdosage may give rise to further complications which include Eosinophilia , Eosinophilia , Increased prothrombin time , Abnormalities of blood coagulation , Anaphylaxis .
Cephaloridine produces potentially life-threatening effects which include Renal damage. Careful monitoring is needed with proper medical management.
The signs and symptoms that are produced after acute overdosage of Cephaloridine are Convulsions , Coma, Myoclonus, Hallucinations , Fever, Nystagmus.
Cephaloridine is known to cause more or less tolerable side effects which are usually transient. These include Allergic diathesis, Cross reactions, Skin rash.
Warnings / Precautions
Available Brands
None recorded.
Storage Conditions
Drug Classification
- 1.6.2.1.3 — Cephalosporins