Docusate (Na)
Docusate (Na) is a laxative, used in the treatment of constipation or fecal impaction. It acts primarily by increasing the penetration of fluid into faeces, also may affect other intestinal fluid secretions and probably acts both as stimulant and faecal softening agents. Docusate (Na) is also used as an adjunct for bowel evacuation prior to abdominal radiological procedures.
Primary Characteristics
Docusate (Na) is also known as Diotyl sodium sulfosuccinate.
It is of Synthetic origin.
Molecular Weight: 444.56 · Solubility in Water: 1 in 70 Slightly soluble · Solubility in Alcohol: freely · Non-proprietary name: Docusate (Na).
Pharmacokinetics
None recorded.
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Indications
Docusate (Na) is primarily indicated in conditions like Constipation.
Contraindications
Docusate (Na) is contraindicated in conditions like Peptic ulcer, Ulcerative colitis, Appendicitis, Hemochromatosis, Haemolytic anaemia.
Dosage
Docusate (Na)'s dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 400 mg/day | 400 mg/day | Every 24h | ( Use as an adjunct to abnormal radiological processes with bariumeal) | |
| 2.75 % | 2.75 % | — | Ear drops | |
| 275 mg/day | 275 mg/day | Every 24h | Oral | 1 or 4 divided doses . |
| Paediatric Dosage (20kg) | ||||
| 12.5 – 25 mg | — | Every 8h | 2 to 12 year of age | |
| 12.5 mg | 12.5 mg | Every 8h | 6th month to 2 year | |
| 120 mg | 120 mg | — | Enema rectally | |
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Docusate (Na) in overdosage may give rise to further complications which include Anorectal pain.
The signs and symptoms that are produced after acute overdosage of Docusate (Na) are Dehydration.
Docusate (Na) is known to cause more or less tolerable side effects which are usually transient. These include Abdominal cramps, Diarrhea, Nausea, Skin RashX.
Warnings / Precautions
Available Brands
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Single Ingredient
Storage Conditions
Drug Classification
- 1.17.6 — Laxatives
Manufacturers
Manufacturers of Docusate (Na) in Pakistan: