Iron Dextran

Drug #1475

Iron Dextran is a complex of ferric hydroxide with dextran. It should be used only in the treatment of proven iron-deficiency anaemia, where oral therapy is ineffective or inappropriate.Iron Dextran is given through deep IM injection. Parenteral iron produces clinical responses similar to that of oral iron, but stores are rapidly repleted after the administration of parenteral iron, which may take months to achieve with oral iron therapy. Anaphylactoid reactions can take place following parenteral administration of it. It was approved by FDA in early 80s.

← Previous drug Next drug →

Primary Characteristics

It is of Synthetic origin and belongs to Ferric hydroxide, Dextran.

Molecular Weight: 133 · Solubility in Water: Soluble · Non-proprietary name: Iron Dextran.

Pharmacokinetics

Distribution: Iron Dextran has a plasma protein binding is 10%.

Indications

Iron Dextran is primarily indicated in conditions like Anaemia, Iron deficiency anaemia.

Contraindications

Iron Dextran is contraindicated in conditions like Asthma, Liver diseases.

Dosage

Iron Dextran's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
100 mg	100 mg	Every 24h	IM
150 mg	150 mg	—	IV	2 or 3 times a day
Paediatric Dosage (20kg)
55 mg	55 mg	Every 24h	IV	Dose varies according to weight.
Neonatal Dosage (3kg)
No data.

Drug Interactions

Unknown2 interactions

1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Iron Dextran in overdosage may give rise to further complications which include Tachycardia , Hypotension , Hypotension , Bradycardia , Thrombophlebitis , Hypertension , Shock , Myocardial infarction , Peripheral vascular flushing, Tachycardia.

Iron Dextran produces potentially life-threatening effects which include Decreased BP , Fatal allergic reactions. Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Iron Dextran are Sarcomas.

Iron Dextran is known to cause more or less tolerable side effects which are usually transient. These include Abdominal pain, Arthralgia, Chest pain, Chest tightness, Chills, Diarrhea, Dizziness, Fever, Flushing, Headache, Metallic taste, Myalgia, Nausea, Paresthesias, Phlebitis , Pruritus , Reaction at injection site, Syncope , Taste disturbance, Urticaria, Vomiting , Weakness.

Warnings / Precautions

It should be used with caution in patients with a history of allergic disorders or asthma and in these patients the intramuscular and not the intravenous rout should be employed. Large doses of iron dextran by infusion may lead to serum discololartion. Prior to beginning treatment patients should receive a test dose and should be observed for adverse reactions. Patient should be kept under observation for atleast 1 hour after administration of test dose.

Interference in Pathology

Iron Dextran may interfere in the diagnosis of Falsely elevated values of serum bilirubin, Falsely decreased values of serum calcium.

Available Brands

Click on a strength to view available brands.

Single Ingredient

Inj

100 mg

Storage Conditions

Iron Dextran should be stored IV Inj, IM Inj.

Drug Classification

1.10.1 — Antianemia drugs

Manufacturers

Manufacturers of Iron Dextran in Pakistan:

Mission