Ropivacaine (HCl Monohydrate)

Drug #1474

Ropivacaine (HCl Monohydrate) is a long-acting amide type local anaesthetic agent. It blocks pain by causing numbness or loss of feeling in an area of the body. Given before, during, or after surgery or childbirth, or at other times when pain needs to be controlled. Ropivacaine (HCl Monohydrate) is used for epidural block, peripheral nerve block and field blocks. At higher doses it produces surgical anaesthesia, whereas at lower doses Ropivacaine (HCl Monohydrate) is used for the management of acute pain such as labour pain and postoperative pain. Like Bupivacaine, ropivacaine has a differential blocking effect on nerve fibres and, at the lowest concentration used, there is good differentiation between sensory and motor block.

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Primary Characteristics

It is of Synthetic origin and belongs to Amide.

Molecular Weight: 328.9 · pK_a: 8.1 · Solubility in Water: 1 in 19 · Non-proprietary name: Ropivacaine (HCl Monohydrate).

Molecular structure of Ropivacaine (HCl Monohydrate)

Pharmacokinetics

Distribution: Ropivacaine (HCl Monohydrate) has a volume of distribution is 41 litre. plasma protein binding is 94 %.

Elimination: it is metabolised via 86 %, plasma half-life is 1.85 hr, renal excretion is 1 %.

Indications

Ropivacaine (HCl Monohydrate) is primarily indicated in conditions like Acute pain, Epidural analgesia in labor, Field block, Peripheral nerve block, Post operative analgesia, Post-operative epidural infusion, Surgical anaesthesia, Wound infiltration.

Contraindications

Ropivacaine (HCl Monohydrate) is contraindicated in conditions like Hypersensitivity.

Dosage

None recorded.

Drug Interactions

Unknown2 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Ropivacaine (HCl Monohydrate) produces potentially life-threatening effects which include Convulsions , Cardiac depression. Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Ropivacaine (HCl Monohydrate) are Dizziness, Visual distrubances, Paresthesia, Loss of conciousness.

Ropivacaine (HCl Monohydrate) is known to cause more or less tolerable side effects which are usually transient. These include Bradycardia , Dizziness, Headache, Hypotension , Nausea and vomiting, Pruritus .

Warnings / Precautions

Avoid in patient with known hypersensitivity. It should be given with caution to the elderly, to debilitated, to children, patients with epilepsy, impaired cardiac conduction or respiratory function, shock or liver damage. The application of local anesthatics to the skin for prolonged period or to the extensive area should be avoided.

Available Brands

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Single Ingredient

Inj

5 mg/ml

Storage Conditions

Ropivacaine (HCl Monohydrate) should be stored Inj, Inf.

Drug Classification

1.1.2 — Local anesthetics

Manufacturers

Manufacturers of Ropivacaine (HCl Monohydrate) in Pakistan:

Lahore Pharma