Rifabutin

Drug #1473

Rifabutin is rifamycin antibiotic with a spectrum of antibacterial activity similar to that of rifampicin. Rifabutin is used for the prophylaxis of Mycobacterium avium complex (MAC) infection in immunocompromised patients and for the treatment of opportunistic mycobacterial infections including tuberculosis (T.B).

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Primary Characteristics

It is of Semi Synthetic origin.

Molecular Weight: 847 · pK_a: - 6.9 · Solubility in Water: slighty · Solubility in Alcohol: sparingly · Non-proprietary name: Rifabutin.

Pharmacokinetics

Absorption: Rifabutin has an oral bioavailability is 25% (±25%), pre-systemic (first-pass) metabolism accounts for 30% (±30%).

Distribution: Rifabutin has a volume of distribution is 8-9 l/kg. plasma protein binding is 70 %.

Elimination: plasma half-life is 36 hr.

Indications

Rifabutin is primarily indicated in conditions like Infection with non-t.b. Mycobacteria, Prophylaxis of TB, Pulmonary TB.

Rifabutin is also indicated for secondary conditions like Adjunct in the treatment of opiod dependence, Adjunctive therapy without valproate, Brucellosis, Cytotoxic-induced neutropenia, Legionellae, Leprosy, Reversal of non-depolarizing neuromuscular blockade, Staphylococcal infections.

Contraindications

None recorded.

Dosage

None recorded.

Drug Interactions

Unknown14 interactions

7 interactions

Major1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Rifabutin in overdosage may give rise to further complications which include Anemia , Leucopenia, Shock , Thrombocytopenia , Jaundice , Uveitis.

Rifabutin produces potentially life-threatening effects which include Bone marrow dyscrosis. Careful monitoring is needed with proper medical management.

Rifabutin is known to cause more or less tolerable side effects which are usually transient. These include Erythema, Fever, Myalgia, Nausea and vomiting.

Warnings / Precautions

It should be used with caution in patients with liver problems. It should be used during pregnancy or lactation only if clearly needed. Alcohol can reduce the effectiveness of this medication and increase side effects, minimize alcohol consumption while taking drug. Rifabutin can decrease the effectiveness of oral contraceptives.

Available Brands

None recorded.

Storage Conditions

Rifabutin should be stored Caps.

Drug Classification

1.6.2.4 — Anti-tuberculosis drugs