Fludarabine

Also known as: Fludara

Drug #1453

Fludarabine is a synthetic purine nucleoside antineoplastic agent. It belongs to the antimetabolite class of neoplastics and is similar in spectrum of activity and adverse effects to cladribine or pentostatin. Fludarabine is structurally similar to vidarabine (an antiviral agent) and cytarabine. Fludarabine is used for chronic low-grade lymphocytic malignancies. Fludarabine is licensed for the initial treatment of advanced ß-cell chronic lymphocytic leukaemia (CLL).

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Primary Characteristics

Fludarabine is also known as Fludara, Fludarabine Phosphate.

It is of Synthetic origin and belongs to Purine analogue.

Molecular Weight: 365.2 · pK_a: 3.2 · Solubility in Water: 1 in 10 · Solubility in Alcohol: Insoluble · Non-proprietary name: Fludarabine.

Pharmacokinetics

Absorption: Fludarabine has an oral bioavailability is 56.25% (±18.75%), pre-systemic (first-pass) metabolism accounts for 75% (±25%).

Distribution: Fludarabine has a volume of distribution is 1.2 - 2 l/kg.

Elimination: it is metabolised via 100%, plasma half-life is 10.4 hr (6.9-19.1 hr), renal excretion is 24%.

Indications

Fludarabine is primarily indicated in conditions like Chronic lymphocytic leukaemia, Lymphoid malgnancies.

Fludarabine is also indicated for secondary conditions like Acute leukemia, Fever, fever, Fever, fever, Indolent lymphoma, Myclodysplastic syndrome, Myelodysplastic syndrome, Myeloid leukaemia.

Contraindications

Fludarabine is contraindicated in conditions like Peripheral neuropathy, HIV infection, Renal impairment, Central neuropathy.

Dosage

Fludarabine's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
25 mg/ sq.meter	25 mg/ sq.meter	—	Slow IV	For 5 days
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

Unknown2 interactions

1 interaction

Major1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Fludarabine in overdosage may give rise to further complications which include Hyperkalemia , Skin rashes , Blindness , Coma , Seizures , Neurotoxicity , Deaths , Hyperuricemia, Hyperphosphatemia, Urate nephropathy , Hemorrhagic cystitis.

Fludarabine produces potentially life-threatening effects which include Coma, Seizures , Thrombocytopenia , Neurotoxicity , Blindness, Immunosuppression, Lymphocytopenia, Myelotoxicity. Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Fludarabine are Death , Coma, Seizures, Neurotoxicity, Thrombocytopenia , Neutropenia , Blindness, Myelotoxicity.

Fludarabine is known to cause more or less tolerable side effects which are usually transient. These include Cough , Dyspnea, Fatigue, Fever, Nausea, Neurotoxicity, Pulmonary hypersensitivity, Somnolence , StomatitisX, Weight LossX.

Warnings / Precautions

Blood counts and measurement of hemoglobulin should be carried out regularly to assist the onset of bone marrow depression. Great care is required when marrow is already depressed following radiotherapy or therapy with other anticancer drugs. Drug must be handled with great care and contact with skin and eye avoided and should not be inhaled. Dosage should be reduced by up to 50% in patient iwth mild to moderate renal impairment and should not be given if creatinine clearance is less than 30 mL/min.

Interference in Pathology

Fludarabine may interfere in the diagnosis of Monitoring of hematologic profile.

Available Brands

Click on a strength to view available brands.

Single Ingredient

Inj

50 mg

Storage Conditions

Fludarabine should be stored Inj (reconstituted soln).

Drug Classification

1.8.2 — Cytotoxic (anti-neoplastic) drugs

Manufacturers

Manufacturers of Fludarabine in Pakistan:

Aventis GHANI BROTHERS Haji ONCOGENE