Fenofibrate
Fenofibrate is an antihyperlipidaemic drug, belongs to fibrates. It acts mainly by decreasing serum triglycerides; it has variable effects on LDL-cholesterol. Fenofibrate is used in hyperlipdaemias of type II a, II b, III, IV and V in patients who have not respond adequately to the dietand other appropriate measures. It may also reduce the risk of coronary heart disease events in those with low HDL-cholesterol or with raised triglycerides.
Primary Characteristics
Fenofibrate is also known as Fenofibrate (Micronized).
It is of Synthetic origin.
Molecular Weight: 360.8 · Solubility in Water: Insoluble · Solubility in Alcohol: slighty · Non-proprietary name: Fenofibrate.
Pharmacokinetics
Absorption: Fenofibrate has an oral bioavailability is 75% (±15%), pre-systemic (first-pass) metabolism accounts for 50% (±50%).
Distribution: Fenofibrate has a volume of distribution is 0.89 l/kg. plasma protein binding is 99 %.
Elimination: plasma half-life is 22.1 hr, renal excretion is 65 %.
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Indications
Fenofibrate is primarily indicated in conditions like Hypercholesterolaemia, Hyperlipoproteinaemia, Prophylaxis of NSAID-associated gastric or duodenal ulcer, Prophylaxis of NSAID-associated gastric or duodenal ulcer.
Contraindications
Fenofibrate is contraindicated in conditions like Gall stones, Liver diseases, Renal impairment, Hypersensitivity, Pregnancy.
Dosage
Fenofibrate's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 300 mg | 300 mg | Every 24h | PO | Initial |
| 300 mg | 300 mg | Every 24h | PO | After 2-3 months after arsaying serum lipids. |
| Paediatric Dosage (20kg) | ||||
| No data. | ||||
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Fenofibrate in overdosage may give rise to further complications which include Hepatitis , Rhabdomyolysis .
Fenofibrate is known to cause more or less tolerable side effects which are usually transient. These include Constipation , Decrease in libido, Diarrhea, Headache, Impotence, Myalgia, Skin rashes.
Warnings / Precautions
Interference in Pathology
Fenofibrate may interfere in the diagnosis of Increased in Serum Aminotransferase.
Available Brands
Storage Conditions
Drug Classification
- 1.12.6 — Lipid-regulating drugs /Anti-atheromas