Esmolol
Esmolol is a cardioselective short-acting beta-blocker. Esmolol is administered via IV-infusion and due to ultra short duration of action, is useful for acute control of hypertension or certain supraventricular arrhythmias. Esmolol is also used to control hypertension and tachycardia in perioperative, postoperative or emergency settings.
Primary Characteristics
It is of Synthetic origin and belongs to Benzenepropanoic Acid.
Molecular Weight: 331.8 · pKa: 9.5 · Solubility in Water: very soluble · Solubility in Alcohol: freely soluble · Non-proprietary name: Esmolol.
Pharmacokinetics
Distribution: Esmolol has a volume of distribution is 3.4 l/kg. plasma protein binding is 55%.
Elimination: plasma half-life is 9 min, renal excretion is 1% (unchanged).
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Indications
Esmolol is primarily indicated in conditions like Adjunct to prevent relapse, Atrial fibrillation, Atrial flutter, Intraoperative tachycardia and/or hypertension, Mild to moderate dementia in alzheimer's disease, Paroxysmal supraventricular tachycardia, Postoperative tachycardia and/or hypertension, Short-term treatment of supraventricular arrhythmias, Tobacco amblyopia and leber's optic atrophy.
Contraindications
Esmolol is contraindicated in conditions like Diabetes mellitus, Cardiogenic shock, Bronchospasm, Heart block, Hypotension, Sinus bradycardia.
Dosage
Esmolol's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 1.5 mg/kg | 1.5 mg/kg | — | IV | For the management of postintubation tachycardia and hypertension, should be given as a bolus injection (over 30 seconds) 1 to 2 minutes before intubation. |
| 10 mg/ml | 10 mg/ml | — | IV | Management of Perioperative Tachycardia and Hypertension: Intubation: Should be administered by a bolus injection over 30 seconds. |
| Paediatric Dosage (20kg) | ||||
| 25 – 350 mcg/kg/min | — | — | IV | |
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Esmolol in overdosage may give rise to further complications which include Hypotension , Hypotension .
Esmolol produces potentially life-threatening effects which include Bradycardia . Careful monitoring is needed with proper medical management.
The signs and symptoms that are produced after acute overdosage of Esmolol are Bradycardia, Hypotension, Drowsiness, Drowsiness, Loss of conciousness.
Esmolol is known to cause more or less tolerable side effects which are usually transient. These include Diaphoresis, dizziness, Dyspnea, Hypotension , Inflammation, Irritability, Necrosis , Paresthesias, Peripheral ischemia, Thrombophlebitis , Weakness.
Warnings / Precautions
Available Brands
None recorded.
Storage Conditions
Drug Classification
- 1.12.3.1 — Beta blocking agents