Enoximone

Drug #1451

Enoximone is a phosphodiesterase inhibitor similar to amrinone, with +ve ionotropic and vasodilator activity. Enoximone is administered intravenosly in the management of heart failure.

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Primary Characteristics

It is of Synthetic origin and belongs to Imidazol.

Molecular Weight: 248.3 · pK_a: 10.3 · Solubility in Water: 1 in 1000 · Solubility in Alcohol: 1 in 200 · Non-proprietary name: Enoximone.

Pharmacokinetics

Absorption: Enoximone has an oral bioavailability is 84% (±4%).

Distribution: Enoximone has a volume of distribution is 1.8 ± 0.7 l/kg. plasma protein binding is 85%.

Elimination: it is metabolised via liver, plasma half-life is 1-4 hr, renal excretion is 71%.

Indications

Enoximone is primarily indicated in conditions like Acute heart failure.

Contraindications

Enoximone is contraindicated in conditions like Epilepsy, Hypovolaemia.

Dosage

Enoximone's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
500 – 500 mg/kg	—	—	IV	This is the dose after initial dose. It can be given every 30 minutes until a satisfactor response is obtained. Maximum total Dose: 3 mg/kg.
0.75 mg/kg	0.75 mg/kg	—	IV	This is an initial doses given at the rate not greater than 12.5 mg/minute.
12.5 mcg/kg /min	12.5 mcg/kg /min	—	IV	Maintenance dose may be repeated every 3-6 hours or a continous or intermitlent infusion.
90 mcg/kg/min	90 mcg/kg/min	—	IV Infusion	This is initial dose given over 10-30 minutes until desired response is achieved. Maximum : 3 mg/kg total dose
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

None recorded.

Side Effects

Enoximone in overdosage may give rise to further complications which include Hypotension , Hypotension , Tonic-clonic seizures , Arruthmia.

Enoximone produces potentially life-threatening effects which include Ventricular tachycardia. Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Enoximone are Hypotension, Ventricular, Arrhythmias.

Enoximone is known to cause more or less tolerable side effects which are usually transient. These include Abdominal pain, Abnormal liver enzyme values, Chills, Diarrhea, Fever, Headache, Irritation, Local thrombophlebitis, Nausea, Oliguria, Pain in upper & lower extremities, Sleep disturbance, Thrombocytopenia, Urinary retention, Vomiting .

Warnings / Precautions

Blood pressure, heart rate, ECG, fliud and electrolyte status, platelet count and liver function should be monitored during therapy. It should be used with caution in patients with liver or renal disease, hypertrophic cardiomypathy or severe obstructive aortic or pulmonary valvular disease.

Available Brands

None recorded.

Storage Conditions

Enoximone should be stored IV Inj, IV Inf.

Drug Classification

1.12.4 — Drugs used in heart failure