Ceftizoxime (Na)
Ceftizoxime is a third generation, semisynthetic cephalosporin antibiotic. Cephalosporins are derivatives of 7-aminocephalosporic acid and are closely related to penicillins in structure. Cephalosporins have a six membered sulfur containing ring adjoining a ß lactam ring. Ceftizoxime is a broad spectrum, ß lactamase resistant antibiotic effective against a wide range of aerobic and anaerobic gram positive and gram negative bacterias. Antibiotics require constant drug level in body for therapeutic effect. This is achieved by taking the medication at regular interval of time throughout the day and night as prescribed. Ceftizoxime (Na) is important to take the drug for the full time period as prescribed. If you discontinue the therapy, it may result in ineffective treatment.
Primary Characteristics
It is of Semi Synthetic origin and belongs to cephalosporine.
It belongs to Peptidoglycan synthesis inhibitor pharmacological group on the basis of mechanism of action and also classified in Antibiotic, Cephalosporin-3rd Gen pharmacological group.
Molecular Weight: 405.4 · pKa: 2.95 · Solubility in Water: 1 in 2 · Solubility in Alcohol: 1 in 10000 · Non-proprietary name: Ceftizoxime (Na).
Pharmacokinetics
Distribution: Ceftizoxime (Na) has a volume of distribution is 021-0.4 l/kg. plasma protein binding is 30%.
Elimination: it is metabolised via negligible, plasma half-life is 1.3-1.6 hr, renal excretion is >90%.
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Indications
Ceftizoxime (Na) is primarily indicated in conditions like Bacteremia, Genitourinary tract infections, Intra-abdominal infections, Lower respiratory tract infections, Septicaemia, Skin infections, Soft tissue infections.
Ceftizoxime (Na) is also indicated for secondary conditions like Bacterial infections, Bone and joint infection, Gonorrhoea, Gynecological infections, Meningitis, Surgical prophylaxis.
Contraindications
Ceftizoxime (Na) is contraindicated in conditions like Hypersensitivity to any component of product.
Dosage
Ceftizoxime (Na)'s dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 1.5 g | 1.5 g | Every 8h | IV | serve conditions |
| 2 g | 2 g | Every 4h | IV | Life threatening conditions |
| Paediatric Dosage (20kg) | ||||
| 50 mg/kg | 50 mg/kg | Every 8h | Intra Muscular | - |
| 50 mg/kg | 50 mg/kg | Every 8h | Intra Venous | - |
| Neonatal Dosage (3kg) | ||||
| 50 mg/kg | 50 mg/kg | Every 8h | Intramuscular | |
| 50 mg/kg | 50 mg/kg | Every 8h | Intravenous | |
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Ceftizoxime (Na) in overdosage may give rise to further complications which include Leucopenia, Thrombocytosis , Thrombocytopenia , Hypersensitivity reactions , Eosinophilia , Neutropenia .
Ceftizoxime (Na) produces potentially life-threatening effects which include Pseudomembranous colitis , Anaphylaxis , Diarrhea. Careful monitoring is needed with proper medical management.
Ceftizoxime (Na) is known to cause more or less tolerable side effects which are usually transient. These include Diarrhea, Elevated alkaline phosphatase, Elevated SGPT & SGOT, Fever, Local reactions, Nausea and vomiting, Pruritus , Rashes .
Warnings / Precautions
Interference in Pathology
Ceftizoxime (Na) may interfere in the diagnosis of Interference with copper reduction tests for urinary glucose. .
Available Brands
Storage Conditions
Drug Classification
- 1.6.2.1.3 — Cephalosporins