Ceftriaxone (Na)
Also known as: Ceftriaxone
Ceftriaxone is a third generation, semisynthetic cephalosporin antibiotic. Cephalosporins are derivatives of 7-aminocephalosporic acid and are closely related to penicillins in structure. Cephalosporins have a six membered sulfur containing ring adjoining a ß lactam ring. Ceftriaxone is a broad spectrum, ß lactmase resistant antibiotic effective against a wide range of gram positive and gram negative bacterias. Antibiotics require constant drug level in body for therapeutic effect. This is achieved by taking the medication at regular interval of time throughout the day and night as prescribed. Ceftriaxone (Na) is important to take the drug for the full time period as prescribed. If you discontinue the therapy, it may result in ineffective treatment.
Primary Characteristics
Ceftriaxone (Na) is also known as Ceftriaxone.
It is of Semi Synthetic origin and belongs to Cephalosporin.
It belongs to Peptidoglycan synthesis inhibitor pharmacological group on the basis of mechanism of action and also classified in Antibiotic, Cephalosporin-3rd Gen pharmacological group.
Molecular Weight: 661.6 · Solubility in Water: freely soluble · Solubility in Alcohol: very slightly soluble · Non-proprietary name: Ceftriaxone (Na) · pH: 6.
Pharmacokinetics
Distribution: Ceftriaxone (Na) has a volume of distribution is 0.15 l/kg. plasma protein binding is 95%.
Elimination: it is metabolised via hepatic, plasma half-life is 6-9 hr, renal excretion is 40% to 65% excreted unchanged in urine.
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Indications
Ceftriaxone (Na) is primarily indicated in conditions like Bacteremia, Benign gastric, duodenal or NSAID-associated ulceration, Bone and joint infection, Chancroid, Endocarditis, Enteric fever, Gonococcal infections, Gonorrhoea, Lower respiratory tract infections, Lyme disease, Meningitis, Pneumonia, Pophylaxis of cardiac transplant rejection, Pophylaxis of hepatic transplant rejection, Septicaemia, Skin infections, Soft tissue infections, Surgical prophylaxis, Sympathetic block, Syphilis, Typhoid fever, Urinary tract infection.
Contraindications
Ceftriaxone (Na) is contraindicated in conditions like Hypersensitivity.
Dosage
Ceftriaxone (Na)'s dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 1 g | 1 g | Every 24h | 0.5-2 pre-operatively for prophylaxis against infection in surgery. | |
| 0.25 – 0 g | — | — | IM | For uncompleted Gonnorrhoea |
| 1.5 g | 1.5 g | Every 24h | IV,IM | Once daily or in two divided doses. Max. dose: 4 g/day. Given by IV infusion over atleast 30 minutes. |
| Paediatric Dosage (20kg) | ||||
| 125 mg | 125 mg | — | For prevention of secondary cases of mennigococcal meningitis | |
| 35 mg/kg | 35 mg/kg | Every 24h | Intra Venous | For serve infections up to 80mg/kg daily should be given |
| Neonatal Dosage (3kg) | ||||
| 50 mg/kg | 50 mg/kg | Every 24h | Intra Venous | IV doses should be given over 60 min doses above 50mg/kg should be given by IV infusion only |
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Ceftriaxone (Na) in overdosage may give rise to further complications which include Eosinophilia , Thrombocytosis , Erythema multiforme , Jaundice , Eosinophilia , Leucopenia, Neutropenia , Erythema multiforme, Jaundice , Biliary pseudolithiasis , Hyperbilirubinemia.
Ceftriaxone (Na) produces potentially life-threatening effects which include Agranulocytosis, Pseudomembranous colitis . Careful monitoring is needed with proper medical management.
The signs and symptoms that are produced after acute overdosage of Ceftriaxone (Na) are Burning sensation.
Ceftriaxone (Na) is known to cause more or less tolerable side effects which are usually transient. These include Diarrhea, Edema, Glossitis, Local pain, Local phlebitis, Loose stools, Maculopapular rash, Nausea, Pruritus , StomatitisX, Urticaria, Vomiting .
Warnings / Precautions
Interference in Pathology
Ceftriaxone (Na) may interfere in the diagnosis of False low reading of urinary glucose testing by Clinitest .
Available Brands
Storage Conditions
Drug Classification
- 1.6.2.1.3 — Cephalosporins
Manufacturers
Manufacturers of Ceftriaxone (Na) in Pakistan: