Cefprozil (Monohydrate)
Cefprozil (Monohydrate) is an oral second generation cephalosporin antibiotic. Cefprozil (Monohydrate) is useful for urinary tract infections which donot respond to other drug.
Primary Characteristics
It is of Semi Synthetic origin and belongs to Cephalosporin.
Molecular Weight: 407.5 · pKa: 2.8, 7.3, 9.7 · Solubility in Water: 1 in 164000 · Solubility in Alcohol: insoluble · Non-proprietary name: Cefprozil (Monohydrate).
Pharmacokinetics
Absorption: Cefprozil (Monohydrate) has an oral bioavailability is 90%.
Distribution: Cefprozil (Monohydrate) has a volume of distribution is 15-20 litre. plasma protein binding is 36-44%.
Elimination: plasma half-life is 1.2 hr, renal excretion is 78% (unchanged) , 20% (in feces).
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Indications
Cefprozil (Monohydrate) is primarily indicated in conditions like Acute exacerbation of chronic bronchitis, Chronic bronchitis, Epidural block, surgery, Lower respiratory tract infections, Otitis media, Pharyngitis, Pneumonia, Skin and soft tissue infections, Skin infections, Tonsillitis, Upper respiratory tract infections, Upper UTIs.
Contraindications
Cefprozil (Monohydrate) is contraindicated in conditions like Hypersensitivity.
Dosage
Cefprozil (Monohydrate)'s dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 500 mg | 500 mg | Every 1h | can be increased twice daily | |
| Paediatric Dosage (20kg) | ||||
| 20 mg/kg | 20 mg/kg | Every 24h | to maximum of 500 mg once a twice daily | |
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Cefprozil (Monohydrate) in overdosage may give rise to further complications which include Serum sickness .
Cefprozil (Monohydrate) produces potentially life-threatening effects which include Pseudomembranous colitis . Careful monitoring is needed with proper medical management.
Cefprozil (Monohydrate) is known to cause more or less tolerable side effects which are usually transient. These include Abdominal pain, Diarrhea, Dizziness, Genital pruritus, Headache, Insomnia, Nausea, Nervousness, Skin rashes, Vaginitis, Vomiting .
Warnings / Precautions
Interference in Pathology
Cefprozil (Monohydrate) may interfere in the diagnosis of False +ve Coombs Test , False +ve Urinary Glucose Test (Clinitest) .
Available Brands
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Single Ingredient
Storage Conditions
Drug Classification
- 1.6.2.1.3 — Cephalosporins