Cefodizime (Na)
Cefodizime (Na) is a third generation cephalosporin antibiotic with actions, uses and adverse effects similar to those of cefotaxime. Cefodizime (Na) is given parentrally in the treatment of susceptible infections.
Primary Characteristics
It is of Semi Synthetic origin and belongs to Aminothiazolyl cephalosporin.
Molecular Weight: 628.6 · pKa: 2.85, 3.37, 4.18 · Solubility in Water: 1 in 3.7 · Non-proprietary name: Cefodizime (Na).
Pharmacokinetics
Distribution: Cefodizime (Na) has a volume of distribution is 7.83-15.8 liter. plasma protein binding is 73-89%.
Elimination: plasma half-life is 2.4 - 4.2 hr, renal excretion is 80% (unchanged).
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Indications
Cefodizime (Na) is primarily indicated in conditions like Pelvic infections, Respiratory tract infections, Urinary tract infection.
Contraindications
Cefodizime (Na) is contraindicated in conditions like Impaired renal function, Hypersensitivity.
Dosage
None recorded.
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Cefodizime (Na) in overdosage may give rise to further complications which include Hemolytic anemia , Angioedema , Leucopenia, Eosinophilia , Anaphylaxis , Allergy , Thrombocytopenia .
Cefodizime (Na) produces potentially life-threatening effects which include Anaphylactic shock. Careful monitoring is needed with proper medical management.
The signs and symptoms that are produced after acute overdosage of Cefodizime (Na) are Encephalopathy.
Cefodizime (Na) is known to cause more or less tolerable side effects which are usually transient. These include Cutaneous eruption, Diarrhea, Dizziness, Headache, Nausea, Skin RashX, Vertigo, Vomiting .
Warnings / Precautions
Interference in Pathology
Cefodizime (Na) may interfere in the diagnosis of Jaffe method for determining Creatinine.
Available Brands
None recorded.
Storage Conditions
Drug Classification
- 1.6.2.1.3 — Cephalosporins