Celiprolol (HCl)

Drug #1440

Celiprolol (HCl) is a cardioselective beta blocker. It possesses intrinsic sympathomimetic and direct vasodilator activity. It is, therefore, used in the treatment of hypertension and angina pectoris.

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Primary Characteristics

It is of Synthetic origin and belongs to Diethylurea.

Molecular Weight: 416 · pK_a: 9.7 · Solubility in Water: 151 g/L · Solubility in Alcohol: 16 g/L · Non-proprietary name: Celiprolol (HCl).

Pharmacokinetics

Absorption: Celiprolol (HCl) has an oral bioavailability is 50% (±20%).

Distribution: Celiprolol (HCl) has a plasma protein binding is 25%.

Elimination: it is metabolised via less, plasma half-life is 4-5 hr, renal excretion is entirely unchanged.

Indications

Celiprolol (HCl) is primarily indicated in conditions like Angina pectoris, Hypertension, Mild to moderate hypertension.

Celiprolol (HCl) is also indicated for secondary conditions like Arrhythmias, Supraventricular arrhythmias.

Contraindications

Celiprolol (HCl) is contraindicated in conditions like Asthma, Heart failure, Cardiogenic shock, Bradycardia, Sick sinus syndrome, Renal impairment, Av block of ii &iii degree, Obstructive lung disorders.

Dosage

Celiprolol (HCl)'s dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
300 mg	300 mg	Every 24h	oral	for hypertension
300 mg	300 mg	Every 24h	oral	for angina. Dose may be increased to 400 to 600 mg once daily.
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

Unknown3 interactions

1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Celiprolol (HCl) in overdosage may give rise to further complications which include Bradycardia .

The signs and symptoms that are produced after acute overdosage of Celiprolol (HCl) are Bradycardia, Hypotension.

Celiprolol (HCl) is known to cause more or less tolerable side effects which are usually transient. These include Breathlessness , Cold extremities, Depression, Dizziness, Fatigue, Headache, Hypersensitivity , Palpitation, Tremor.

Warnings / Precautions

It should be used with caution in diabetic patients or patients with impaired liver or kidney function. It should not be given to patient with bronchospasm or asthma or to those with a history of obstructive airways disease.

Available Brands

None recorded.

Storage Conditions

Celiprolol (HCl) should be stored Tab .

Drug Classification

1.12.3.1 — Beta blocking agents