Canrenoate (K)

Drug #1437

Canrenoate (K) is a potassium-sparing diuretic with action and uses similar to those of spironolactone. Canrenoate (K) is used in the treatment of refractory oedema associated with heart failure or hepatic disease.

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Primary Characteristics

It is of Synthetic origin and belongs to Carboxylic acid lactone.

Molecular Weight: 396.2 · pK_a: 5.2 · Solubility in Water: soluble · Solubility in Alcohol: soluble · Non-proprietary name: Canrenoate (K).

Pharmacokinetics

Distribution: Canrenoate (K) has a plasma protein binding is 98%.

Elimination: plasma half-life is 10-35 hr, renal excretion is 88%.

Indications

Canrenoate (K) is primarily indicated in conditions like Magnesium deficiency, Oedema with secondary aldosteronism, Potassium deficiency, Primary hyperaldosteronism.

Contraindications

Canrenoate (K) is contraindicated in conditions like Hyperkalaemia, Renal impairment.

Dosage

None recorded.

Drug Interactions

Unknown3 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Canrenoate (K) in overdosage may give rise to further complications which include Change in voice, Hyperkalemia .

The signs and symptoms that are produced after acute overdosage of Canrenoate (K) are Nausea, Vomiting, Hallucinations , Hyperkalemia, Restlessness , Transient confusion.

Canrenoate (K) is known to cause more or less tolerable side effects which are usually transient. These include Gynecomastia, Menstrual irregularity, Pain at injection site.

Warnings / Precautions

Serum electrolytes and blood urea nitrogen should be measured periodically. It should be used carefully in patient who are at increased risk of developing hyperkalemia, such as elderly, those with diabetes mellitus and those with some degree of renal or hepatic impairment and patients likely to develop acidosis.

Interference in Pathology

Canrenoate (K) may interfere in the diagnosis of Measurement of Serum Digoxin by Immunoassay. .

Available Brands

None recorded.

Storage Conditions

Canrenoate (K) should be stored IV inf .

Drug Classification

1.16.3 — Potassium sparing diuretics