Bupropion (HCl)
Bupropion (HCl) is an antidepressant chemically unrelated to other classes of antidepressants. It weakly inhibits the neuronal reuptake of serotonin, dopamine and noradrenaline.Bupropion (HCl) is also used as an aid to smoking cessation in combination with motivational support.
Primary Characteristics
It is of Synthetic origin and belongs to Amino propanone.
Molecular Weight: 276.2 · pKa: 7.9 · Solubility in Water: < 1 in 3 · Solubility in Alcohol: 1 in 5 · Non-proprietary name: Bupropion (HCl).
Pharmacokinetics
Absorption: Bupropion (HCl) has an oral bioavailability is 47.5% (±47.5%).
Distribution: Bupropion (HCl) has a volume of distribution is 1.4-3.2 l/kg. plasma protein binding is 75-85%.
Elimination: plasma half-life is 8-24 hr, renal excretion is 84%.
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Indications
Bupropion (HCl) is primarily indicated in conditions like Depression.
Contraindications
Bupropion (HCl) is contraindicated in conditions like Brain tumors, Seizures, Head injury, Pregnancy, Breast feeding.
Dosage
Bupropion (HCl)'s dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 150 mg | 150 mg | Every 24h | PO | Initially for 6 days.Then 150 mg BD. Max. daily dose 300 mg. |
| Paediatric Dosage (20kg) | ||||
| No data. | ||||
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Bupropion (HCl) in overdosage may give rise to further complications which include Eosinophilia , Neuropsychiatric disturbances.
Bupropion (HCl) produces potentially life-threatening effects which include Seizures . Careful monitoring is needed with proper medical management.
The signs and symptoms that are produced after acute overdosage of Bupropion (HCl) are Loss of conciousness, Seizures, Cardiovascular collapse, Tachycardia , Hallucinations .
Bupropion (HCl) is known to cause more or less tolerable side effects which are usually transient. These include Agitation , Constipation , Dry mouth, Headache, Insomnia, Menstrual irregularity, Nausea, Tremor, Vomiting , Weight LossX.
Warnings / Precautions
Available Brands
Storage Conditions
Drug Classification
- 1.24.2.1 — Drugs used in depression