Primary Characteristics
It is of Semi Synthetic origin and belongs to Cephalosporin.
It belongs to Peptidoglycan synthesis inhibitor pharmacological group on the basis of mechanism of action and also classified in Antibiotics pharmacological group.
Molecular Weight: 554.5 · pKa: 3.3-4.8 · Solubility in Water: 1 in 2.27 · Solubility in Alcohol: insoluble · Non-proprietary name: Cefsulodin (Na).
Pharmacokinetics
Distribution: Cefsulodin (Na) has a volume of distribution is 0.26 l/kg. plasma protein binding is 25-35%.
Elimination: plasma half-life is 1.6 hr, renal excretion is >90%.
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Indications
Cefsulodin (Na) is primarily indicated in conditions like Bone and joint infection, Cystic fibrosis, Meningitis, Prostatitis, Respiratory tract infections, Septicaemia, Soft tissue infections, Urinary tract infection.
Contraindications
Cefsulodin (Na) is contraindicated in conditions like Hypersensitivity.
Dosage
Cefsulodin (Na)'s dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 6 g | 6 g | Every 6h | Slow IV | 3 to 4 gm In less serve infection |
| Paediatric Dosage (20kg) | ||||
| 100 mg/kg | 100 mg/kg | — | Slow IV | 50 mg/kg in less serve infection. |
| Neonatal Dosage (3kg) | ||||
| 5 mg/kg | 5 mg/kg | Every 12h | oral | Not recommended below 6 months |
Drug Interactions
None recorded.
Side Effects
Cefsulodin (Na) produces potentially life-threatening effects which include Anaphylaxis . Careful monitoring is needed with proper medical management.
Cefsulodin (Na) is known to cause more or less tolerable side effects which are usually transient. These include Allergic reactions, Dizziness, Local pain, Nausea.
Warnings / Precautions
Interference in Pathology
Cefsulodin (Na) may interfere in the diagnosis of False elevated values of creatinine by Jaffe Reaction. , False results for urinary sugars estimation. .
Available Brands
None recorded.
Storage Conditions
Drug Classification
- 1.6.2.1.3 — Cephalosporins