Apraclonidine (HCl)

Drug #1426

Apraclonidine (HCl) is an alpha-2 adrenoceptor agonist, a derivative of clonidine. It reduces the secretions of aqueous humour in the anterior chamber of the eye. Therefore, Apraclonidine (HCl) is used to control intra-ocular pressure (IOP), following laser surgery to the eye. Apraclonidine (HCl) is also used to delay laser treatment or surgery for glaucoma, in patients not adequately controlled by another drug.

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Primary Characteristics

It is of Synthetic origin and belongs to Benzenediamine.

Molecular Weight: 281.58 · pK_a: 1.16, 9.22 · Solubility in Water: 1 in 35 · Solubility in Alcohol: 1 in 75 · Non-proprietary name: Apraclonidine (HCl).

Molecular structure of Apraclonidine (HCl)

Pharmacokinetics

Distribution: Apraclonidine (HCl) has a plasma protein binding is 25%.

Elimination: plasma half-life is 8 hr.

Indications

Apraclonidine (HCl) is primarily indicated in conditions like Glucoma, Post-operative elevation of intraocular pressure.

Contraindications

Apraclonidine (HCl) is contraindicated in conditions like CNS depression, Hypersensitivity.

Dosage

None recorded.

Drug Interactions

Unknown2 interactions

8 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Apraclonidine (HCl) in overdosage may give rise to further complications which include Foreign body sensation, Edema of lids.

Apraclonidine (HCl) produces potentially life-threatening effects which include Hypertensive crises, Stroke. Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Apraclonidine (HCl) are Apnea, Asthenia, Seizures, Irritability, Conduction disturbances, Hypothermia, Sedation , Diminished reflexes, Hypotension, Vomiting, Coma, Dry mouth, Somnolence, Arrhythmias, Bradycardia, Transient hypertension, Lethargy, Pallor.

Apraclonidine (HCl) is known to cause more or less tolerable side effects which are usually transient. These include Asthma, Belching, Blurred vision, Chest pain, Conjunctivitis, Discomfort , Dryness of eye, Facial edema, Foreign body sensation, Headache, Hyperemia, Itching, Keratitis, Malaise, Pain , Pruritus , Tearing.

Warnings / Precautions

It should be used with care in patient with severe cardiovascular disease including hypertension, in patient with a history of vasovagal attacks and in depressed patient.

Available Brands

None recorded.

Storage Conditions

Apraclonidine (HCl) should be stored Eye Soln.

Drug Classification

1.21.7 — Other ophthalmologicals