Apomorphine

Drug #1425

Apomorphine is a morphine derivative and a potent dopamine D2 receptor agonist. Apomorphine is used parenterally for the treatment of parkinsonism, especially in advanced disease, for patients experiencing unpredictable "off " periods with levodopa treatment. It stimulates chemoreceptor trigger zone in the brain and can produce vomiting within a few minutes after administration. Specialist supervision is advisable throughout it treatment. Apomorphine is also used in the management of eractile dysfunction.

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Primary Characteristics

It is of Synthetic origin and belongs to Quinoline.

Molecular Weight: 625.6 · pK_a: 7.2, 8.9 · Solubility in Water: 1 in 50 · Solubility in Alcohol: 1 in 50 · Non-proprietary name: Apomorphine.

Pharmacokinetics

Distribution: Apomorphine has a volume of distribution is 2 l/kg.

Elimination: plasma half-life is 33 min.

Indications

Apomorphine is primarily indicated in conditions like Erectile dysfunction, Parkinsonism, Parkinson's disease, Refractory motor fluctuations in parkinson`s disease.

Contraindications

Apomorphine is contraindicated in conditions like Respiratory disease, Opioid dependence, Cardiac disease.

Dosage

None recorded.

Drug Interactions

8 interactions

Moderate2 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Apomorphine in overdosage may give rise to further complications which include Delayed psychosis.

Apomorphine produces potentially life-threatening effects which include Uremia, Asystole . Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Apomorphine are Acute psychosis, Postural hypotension, Peripheral vasodilation, Protracted vomiting.

Apomorphine is known to cause more or less tolerable side effects which are usually transient. These include Edema, Hallucination , Reaction at injection site.

Warnings / Precautions

It should be used with caution in patient prone to vomiting and nausea or when vomiting is likely to pose a risk, use with care in patient with pulmonary, cardiovascular, endocrine disease or with renal impairment. Extra care is needed during initiation of treatment in elderly or debilitated patient and in those with a history of postural hypotension. Periodic monitoring of renal, hepatic, hemopoietic and cardiovascular function has been advised. Patient who develope anemia or those who have continuing confusion or hallucination during treatment require observation and dosage adjustment under specialist superviision, treatment may need to be discontinue.

Available Brands

None recorded.

Storage Conditions

Apomorphine should be stored SC Inj, SC Inf.

Drug Classification

1.9.1 — Drugs used in parkinsonism