Arbekacin

Drug #1427

Arbekacin is an antibacterial agent, belongs to aminoglycoside antibiotics. Arbekacin is a derivative of dibekacin and has general properties similar to those of gentamicin. Arbekacin is used parenterally in the treatment of serious infections due to methicillin-resistant Staphylococcus aureus.

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Primary Characteristics

It is of Semi Synthetic origin and belongs to Streptamine.

Molecular Weight: 552.6 · pK_a: 8.1 · Solubility in Water: 0.6 in 1 · Solubility in Alcohol: negligible · Non-proprietary name: Arbekacin.

Pharmacokinetics

Distribution: Arbekacin has a volume of distribution is 15 liter. plasma protein binding is 3-12%.

Elimination: plasma half-life is 1.5-3 hr.

Indications

Arbekacin is primarily indicated in conditions like Pneumonia, Septicaemia.

Contraindications

Arbekacin is contraindicated in conditions like Hypersensitivity.

Dosage

None recorded.

Drug Interactions

Unknown6 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Arbekacin in overdosage may give rise to further complications which include Reversible renal tubular injury, Ototoxicity .

Arbekacin produces potentially life-threatening effects which include Neuromuscular blockage, Nephrotoxicity. Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Arbekacin are Nephrotoxicity , Neuromuscular blockade, Ototoxicity.

Arbekacin is known to cause more or less tolerable side effects which are usually transient. These include Diarrhea, Skin rashes.

Warnings / Precautions

Special precaution is required when using in elderly patients with significant impairment of renal function because high serum concentration of arbekacin might cause renal or ototoxicity. In patients with renal insufficiency the dosage and dose interval should be adjusted by monitoring the serum concentration. Arbekacin should be administered in separate drip infusion when co-administration of different drug is contemplated.

Available Brands

None recorded.

Storage Conditions

Arbekacin should be stored .

Drug Classification

1.6.2.2.5 — Aminoglycosides