Para-Amino Salicylic Acid
Para-Amino Salicylic Acid is used in combination for the treatment of tuberculosis, when other more potent drugs cannot be used.
Primary Characteristics
It is of Synthetic origin and belongs to Amino Hydroxybenzoic Acid.
Molecular Weight: 211.2 · pKa: 3.2 · Solubility in Water: 1 in 2 · Solubility in Alcohol: sparingly · Non-proprietary name: Para-Amino Salicylic Acid.
Pharmacokinetics
Distribution: Para-Amino Salicylic Acid has a volume of distribution is 0.24 l/kg. plasma protein binding is 50 - 73%.
Elimination: plasma half-life is 45 - 60 min, renal excretion is 14 - 33% (unchanged), 50% (as metabolite).
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Indications
Para-Amino Salicylic Acid is primarily indicated in conditions like Multi-drug resistance tuberculosis.
Contraindications
Para-Amino Salicylic Acid is contraindicated in conditions like Renal diseases, Hypersensitivity.
Dosage
Para-Amino Salicylic Acid's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 11 g | 11 g | — | PO | Daily in 2-3 div.doses |
| Paediatric Dosage (20kg) | ||||
| No data. | ||||
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Para-Amino Salicylic Acid in overdosage may give rise to further complications which include Hepatotoxicity , Pulmonary infiltration, Rashes, Conjunctivitis, Eosinophilia , Hypersensitivity reactions , Fever , Pruritis .
Para-Amino Salicylic Acid produces potentially life-threatening effects which include Hepatotoxicity , Necrosis, Granular degeneration, Fatty vacuolization. Careful monitoring is needed with proper medical management.
Para-Amino Salicylic Acid is known to cause more or less tolerable side effects which are usually transient. These include Abdominal cramps, Anorexia , Diarrhea, GI upset, Goiter, Macrocytic anemia, Nausea, Vomiting .
Warnings / Precautions
Interference in Pathology
Para-Amino Salicylic Acid may interfere in the diagnosis of Plasma and Serum Tests for Corticosteroids .
Available Brands
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Single Ingredient
Storage Conditions
Drug Classification
- 1.6.2.4 — Anti-tuberculosis drugs
Manufacturers
Manufacturers of Para-Amino Salicylic Acid in Pakistan: