Alglucerase

Drug #1422

Alglucerase is a modified form of human placental enzyme (ß-glucocerebrosidase), and a monomeric glycoprotien containing 497 amino acids with glycosylation. Alglucerase is used as enzyme replacement therapy.

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Primary Characteristics

It is of Natural origin and belongs to Protien.

Molecular Weight: 59300 · pK_a: 7.3 - 7.8 · Solubility in Water: soluble · Solubility in Alcohol: insoluble · Non-proprietary name: Alglucerase.

Pharmacokinetics

Distribution: Alglucerase has a volume of distribution is 49.4 - 282 ml/kg. plasma protein binding is unknown.

Elimination: plasma half-life is 3.6 - 10.4 min.

Indications

Alglucerase is primarily indicated in conditions like Gauchers disease (type I).

Contraindications

Alglucerase is contraindicated in conditions like Prostatic cancer, Skeletal disease, Allergy to serum albumin.

Dosage

Alglucerase's dosage details are as follows:

Dose	Single Dose	Frequency	Instructions
Adult Dosage
0 – 0	—	—	Alglucerase injection is administered by intravenous infusion over 1-2 hours. Dosage should be individualized for each patient. Initial dosage may be as little as 2.5 units/kg of body weight 3 times a week up to as much as 60 units/kg administered as frequently as once a week or as infrequently as every 4 weeks. 60 units/kg every 2 weeks is the dose for which the most data are available
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

None recorded.

Side Effects

Alglucerase in overdosage may give rise to further complications which include Sense of laryngeal constriction, Upper airway inflammation.

Alglucerase is known to cause more or less tolerable side effects which are usually transient. These include Abdominal cramps, Allergic reactions, Angioedema, Chest tightness, Chills, Cough , Discomfort , Fever, Flushing, Headache, Pruritus , Reaction at injection site, Urticaria, Virilization, Vomiting .

Warnings / Precautions

Caution is required in patient who have exhibited sign of hypersenitivity, if hypersensitivity reaction occurs the drug should be discontinued. It is prepared from human placenta therefore carries a risk of transmission of infection. It should be used with caution in patient with androgen-sensitive malignancies. It is classified as pregnancy cateogry C. It should be used with caution during pregnancy and only when the benefit outweighs the risk.

Available Brands

None recorded.

Storage Conditions

Alglucerase should be stored Inj.

Drug Classification

1.99 — Unassigned