Carfecillin (Na)

Drug #134

Carfecillin (Na) is antibiotic and is used to treat bacterial infections. Antibiotics require constant drug level in body for therapeutic effect. This is achieve by taking the drug at regular interval of time throughout the day and night as prescribed. Carfecillin (Na) is important to take the drug for the full time period as prescribed. If you discontinue the drug it may result in ineffective treatment.

← Previous drug Next drug →

Primary Characteristics

It is of Synthetic origin and belongs to Penicillinate.

It belongs to Peptidoglycan synthesis inhibitor pharmacological group on the basis of mechanism of action and also classified in Antibiotic, Penicillin pharmacological group.

Molecular Weight: 476.5 · pK_a: 2.9 · Non-proprietary name: Carfecillin (Na).

Pharmacokinetics

Absorption: Carfecillin (Na) has an oral bioavailability is 95%, pre-systemic (first-pass) metabolism accounts for 95% (±5%).

Distribution: Carfecillin (Na) has a volume of distribution is 0.17 l/kg. plasma protein binding is 50%.

Elimination: plasma half-life is 1.2 hr, renal excretion is >25%.

Indications

Carfecillin (Na) is primarily indicated in conditions like Urinary tract infection.

Contraindications

Carfecillin (Na) is contraindicated in conditions like Bacteremia, Sepsis.

Dosage

Carfecillin (Na)'s dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
10.714 mg/kg	10.714 mg/kg	Every 8h	PO	-
Paediatric Dosage (20kg)
15 mg/kg	15 mg/kg	Every 8h	Oral	-
Neonatal Dosage (3kg)
15 mg/kg	15 mg/kg	Every 8h	Oral	-

Drug Interactions

None recorded.

Side Effects

Carfecillin (Na) produces potentially life-threatening effects which include Hypersensitivity rash. Careful monitoring is needed with proper medical management.

Carfecillin (Na) is known to cause more or less tolerable side effects which are usually transient. These include GI upset, Nausea, Vomiting .

Warnings / Precautions

Adequate fluid intake must be maintained during clodronate treatment. This is particularly important when administering clodronate as intravenous infusion and in the patients with hypercalcemia or renal failure. Intravenous administration of doses notably higher than those recommended may cause severe renal damage especially if the infusion rate is too high.

Available Brands

None recorded.

Storage Conditions

Carfecillin (Na) should be stored .

Drug Classification

1.6.2.1.1 — Penicillins