Carboplatin
Carboplatin is an alkylating anticancerous drug. Carboplatin is a platinium co-ordination compound having the same mechanism of action as cisplatin. Carboplatin is effective in the treatment of ovarian cancer, non-small cell lung cancer, germ cell , head and neck, and oesophageal cancers. Carboplatin is used alone or in combination with different anti-cancerous drugs to obtain best therapeutic effects and to reduce side effects or toxicities.
Primary Characteristics
It is of Synthetic origin and belongs to Cyclobutane Platinum.
It belongs to Cross Linkage (DNA acting) pharmacological group on the basis of mechanism of action and also classified in Antineoplastic Agent, Alkylating Agent pharmacological group.
Molecular Weight: 371.3 · Solubility in Water: < 1 in 10 · Solubility in Alcohol: < 1 in 1000 · Non-proprietary name: Carboplatin.
Pharmacokinetics
Distribution: Carboplatin has a volume of distribution is 0.17l/kg. plasma protein binding is 24%.
Elimination: plasma half-life is 1.5 hr, renal excretion is entire.
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Indications
Carboplatin is primarily indicated in conditions like Advanced ovarian cancer, Head and neck cancer, Lung cancer, Ovarian cancer, Small cell lung cancer.
Carboplatin is also indicated for secondary conditions like Colorectal cancer, Gastric cancer, Malignant lymphoma, Non-small cell lung carcinoma.
Contraindications
Carboplatin is contraindicated in conditions like Allergy.
Dosage
Carboplatin's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 400 mg/sq.meter | 400 mg/sq.meter | — | IV Inf | Once over 15-60 Minutes |
| Paediatric Dosage (20kg) | ||||
| No data. | ||||
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Carboplatin in overdosage may give rise to further complications which include Nephrotoxicity , Gi bleeding , Hepatotoxicity , Ototoxicity , Blood dyscrasias , Peripheral neuropathy .
Carboplatin produces potentially life-threatening effects which include Thrombocytopenia , Myelosuppression . Careful monitoring is needed with proper medical management.
Carboplatin is known to cause more or less tolerable side effects which are usually transient. These include Alopecia, Anorexia , Arthralgia, Asthenia , Blurred vision, Diarrhea, Malaise, Myalgia, Pain at injection site, Rashes , Vomiting .
Warnings / Precautions
Available Brands
Storage Conditions
Drug Classification
- 1.8.2 — Cytotoxic (anti-neoplastic) drugs