Carbenicillin (Na)

Drug #128

Carbenicillin is a semisynthetic penicillin. Alexander Fleming reported his discovery of penicillin in 1929. Chain, Flory and their associates succeeded in producing significant quantities of the first penicillins from the cultures of Penicillium notatum in 1940. Ten years later virtually unlimited quantities of penicillin G were available for clinical use. Carbenecillin is the first antipseudomonal carboxypenicillin. Carbenicillin is effective against gram negative bacteria and also inhibiting the growth of some gram positive bacteria.

← Previous drug Next drug →

Primary Characteristics

It is of Semi Synthetic origin and belongs to Beta Lactam.

It belongs to Peptidoglycan synthesis inhibitor pharmacological group on the basis of mechanism of action and also classified in Antibiotic, Penicillin pharmacological group.

Molecular Weight: 422.4 · pK_a: 2.6 · Solubility in Water: 1 in 1.2 · Solubility in Alcohol: 1 in 25 · Non-proprietary name: Carbenicillin (Na).

Molecular structure of Carbenicillin (Na)

Pharmacokinetics

Distribution: Carbenicillin (Na) has a volume of distribution is 0.18 l/kg. plasma protein binding is 50%.

Elimination: plasma half-life is 1-1.5 hr, renal excretion is largely.

Indications

Carbenicillin (Na) is primarily indicated in conditions like Bacterial infections, Meningitis, Urinary tract infection.

Contraindications

Carbenicillin (Na) is contraindicated in conditions like Haemophilia.

Dosage

Carbenicillin (Na)'s dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
42.85 mg/kg	42.85 mg/kg	Every 6h	Slow IV	As Required
Paediatric Dosage (20kg)
400 mg/kg	400 mg/kg	—	Intra Venous	As Required
Neonatal Dosage (3kg)
No data.

Drug Interactions

Unknown5 interactions

Major1 interaction

Moderate2 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Carbenicillin (Na) in overdosage may give rise to further complications which include Cardiac insufficiency , Granulocytopenia , Coagulation disorder , Hypokalemia , Stevens johnson syndrome .

The signs and symptoms that are produced after acute overdosage of Carbenicillin (Na) are Epileptic seizures, Neurotoxic reactions.

Carbenicillin (Na) is known to cause more or less tolerable side effects which are usually transient. These include Abdominal pain, Bullous rash, Diarrhea, Edema, Elevation of liver enzymes, Flatulence, Fluid retention, Nausea, Phlebitis , Vomiting .

Warnings / Precautions

Carbenicillin should be used with caution in patients with medical history especially of kidney disease, stomach or intestinal problems, blood disorders and of drug allergies, especially allergies to other penicillin or cephalosporin antibiotics. Do not use carbencillin repeatedly or for prolong period because use of this medication for prolonged or repeated periods may result in a secondary infection (e.g.oral, bladder or vaginal yeast infection). It should be used with extreme caution during pregnancy or lactation.

Interference in Pathology

Carbenicillin (Na) may interfere in the diagnosis of Impair the in-vitro assay of aminoglycosides .

Available Brands

None recorded.

Storage Conditions

Carbenicillin (Na) should be stored Tab.

Drug Classification

1.6.2.1.1 — Penicillins