Carbenoxolone (Na)
Carbenoxolone (Na) is a synthetic derivative of glycyrrhizic acid, an agent extracted from licorice, having marked anti-infammatory actions and aldosterone like activity. It has been shown to be effective in healing both gastric and duodenal ulcers.
Primary Characteristics
It is of Semi Synthetic origin and belongs to Glycyrrhetinic Acid.
It belongs to Anti-ulcer (GI) pharmacological group on the basis of mechanism of action and also classified in Antipeptic Ulcerant pharmacological group. It is also classified under Antacids .
Molecular Weight: 614.7 · pKa: 6.7, 7.1 · Solubility in Water: 1 in 6 · Solubility in Alcohol: 1 in 30 · Non-proprietary name: Carbenoxolone (Na) · pH: 6.6 · Isotonic value: 4.4.
Pharmacokinetics
Absorption: Carbenoxolone (Na) has an oral bioavailability is 92.5% (±2.5%).
Distribution: Carbenoxolone (Na) has a volume of distribution is 0.1 l/kg. plasma protein binding is >99%.
Elimination: it is metabolised via Hepatic, plasma half-life is 8-20 hr.
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Indications
Carbenoxolone (Na) is primarily indicated in conditions like Aphthous mouth ulceration, Benign gastric ulcer, Duodenal ulcer, Peptic oesophagitis.
Contraindications
Carbenoxolone (Na) is contraindicated in conditions like Hypertension, Cardiac failure, Hypokalaemia, Renal diseases, Hepatic disease.
Dosage
Carbenoxolone (Na)'s dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 0.11 mg/kg | 0.11 mg/kg | Every 8h | Inhalation | twice a day. |
| 0.714 mg/kg | 0.714 mg/kg | Every 6h | PO | For 6-12 Weeks |
| Paediatric Dosage (20kg) | ||||
| 0 – 0 | — | — | — | Not Recommended in this Age Group |
| Neonatal Dosage (3kg) | ||||
| 0 – 0 | — | — | — | Not Recommended in this Age Group |
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Carbenoxolone (Na) in overdosage may give rise to further complications which include Hypokalemia , Fluid retension , Increased blood pressure .
Carbenoxolone (Na) produces potentially life-threatening effects which include Hypokalemia, Hypertension, Papilloedema , Cardiac failure. Careful monitoring is needed with proper medical management.
The signs and symptoms that are produced after acute overdosage of Carbenoxolone (Na) are Hypokalemia .
Carbenoxolone (Na) is known to cause more or less tolerable side effects which are usually transient. These include Headache, Increased weight, Weight gain.
Warnings / Precautions
Available Brands
None recorded.
Storage Conditions
Drug Classification
- 1.17.1.2 — Anti-peptic ulcerants