DrugInfoSys

Mepyramine

Also known as: Pyrilamine, Pyranisamine

Drug #1243

Mepyramine is a first generation antihistamine targetting H1 receptor.It is an ethylenediamine derivative and is a sedating anti-histamine with antimuscarinic and sedative properties. Mepyramine (Maleate) is used for the symptomatic relief of hypersensitivity reaction and in pruritic skin disorders.

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Primary Characteristics

Mepyramine is also known as Pyrilamine, Pyranisamine, Mepyramine (Maleate).

It is of Synthetic origin and belongs to Ethylene diamine decivation.

Molecular Weight: 285.38 · Solubility in Water: 1 in 0.5 · Solubility in Alcohol: 1 in 3 · Non-proprietary name: Mepyramine · pH: 4.9.

Molecular structure of Mepyramine

Pharmacokinetics

None recorded.

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Indications

Mepyramine is primarily indicated in conditions like Allergy, Cold, Cough, Hypersensitivity reactions, Pruritus.

Contraindications

Mepyramine is contraindicated in conditions like Asthma, Angle-closure glaucoma, Renal impairment, Hepatic impairment, Cardiac disease, Urinary retention.

Dosage

Mepyramine's dosage details are as follows:

DoseSingle DoseFrequencyRouteInstructions
Adult Dosage
37.5 mg37.5 mgEvery 8hPO
50 mg50 mg—POAt night for insomnia
2 %2 %—Topical
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

Unknown2 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Mepyramine in overdosage may give rise to further complications which include Psychosis , Ataxia , Tremors , Angioedema , Palpitation , Urinary retention, Hallucinations , Cardiac arrhythmias, Bronchospasm , Anaphylaxis , Hair loss , Rashes, CNS depression, Myalgia , Blood disorders .

Mepyramine produces potentially life-threatening effects which include Coma, Convulsions , Cardiorespiratory collapse. Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Mepyramine are Extrapyramidal effects , Convulsions , Coma, Ataxia, Hyperpyrexia, Tremor, Excitement.

Mepyramine is known to cause more or less tolerable side effects which are usually transient. These include Blurred vision, Constipation , Dizziness, Drowsiness, Dry mouth, Excitement, Fever, Headache, Incoordination , Lassitude , Nausea and vomiting, Rashes .

Warnings / Precautions

Patients should observed caution while driving or performing other tasks requiring alertness, because may cause drowsiness. Mepyramine should be used with caution in patients with liver impairment, dose should be reduced in patients with renal impairment. Avoid use in young children and use with caution in elderly patients. Topical preparation containing antihistamines should not be used on broken and eczematous skin.

Available Brands

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Single Ingredient

Cream
2 %w/w
Inj
50 mg/ml
Tabs
6.5 mg

Multi-Ingredient Combinations

Powder
13 mg/sachet
Syrup
6.25 mg/5ml6.55 mg/5ml
Tabs
15 mg25 mg6.5 mg

Storage Conditions

Mepyramine should be stored Tab.

Drug Classification

  1. 1.3 — Anti-allergics (Antihistamines) and drugs used in anaphylaxis
  2. 2.25.2.1 — Cold preparations

Manufacturers