Magnesium Sulphate
Magnesium Sulphate is a saline laxative. Magnesium Sulphate is used in constipation. It increases the bulk of intestinal contents and cause defecation. Magnesium Sulphate is also used to control seizures in pregnancy, to treat low magnesium levels, problems related to kidney conditions (nephritis) in children, to prevent premature contractions in pregnancy, to treat heart attack and asthma patients.
Primary Characteristics
It is of Synthetic origin.
Molecular Weight: 246.5 · Solubility in Water: Freely soluble · Solubility in Alcohol: Insoluble · Non-proprietary name: Magnesium Sulphate · pH: 5.
Pharmacokinetics
Distribution: Magnesium Sulphate has a plasma protein binding is 25 - 30 %.
Elimination: renal excretion is Urine.
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Indications
Magnesium Sulphate is primarily indicated in conditions like Constipation, Convulsions, Eclampsia, Emergency treatment of serious arrhythmias, Hyperacidity, Hypomagnesaemia, Nephritis, Prevention of seizure recurrence in pre-eclampsia, Seizures, Suspected myocardial infarction, Symptomatic hypomagnesaemia, To prevent recurrence of defecits.
Magnesium Sulphate is also indicated for secondary conditions like Premature labour.
Contraindications
Magnesium Sulphate is contraindicated in conditions like Myocardial infarction, Heart block, Toxaemia of pregnancy, Renal impairment.
Dosage
Magnesium Sulphate's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 3 g | 3 g | Every 6h | IV,IM | As required |
| 7.5 g | 7.5 g | — | Oral | As an antacid & osmotic laxative ,Given in 250 ml of water. |
| Paediatric Dosage (20kg) | ||||
| No data. | ||||
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Magnesium Sulphate in overdosage may give rise to further complications which include Diarrhoea , Bradycardia , CNS depression, Hypocalcemia , Hypermanganesemia.
Magnesium Sulphate produces potentially life-threatening effects which include Coma, Cardiac Arrest , Cardiac arrest, Respiratory paralysis. Careful monitoring is needed with proper medical management.
The signs and symptoms that are produced after acute overdosage of Magnesium Sulphate are Edema, Cardiac arrest.
Magnesium Sulphate is known to cause more or less tolerable side effects which are usually transient. These include Confusion, Drowsiness, Flushing, Hypotension , Muscle weakness, Nausea and vomiting, Respiratory depression, Slurred speech, Thirst.
Warnings / Precautions
Available Brands
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Multi-Ingredient Combinations
Storage Conditions
Drug Classification
- 1.5 — Anticonvulsants and Antiepileptics
- 2.27 — Vitamins, minerals, tonics, and other susbstances