Calcitriol
Also known as: 1, 25 Dihydroxy Vitamin D3
Calcitriol is a 1, 25-dihydroxycholecalciferol (vitamin D), a fat soluble sterol, sometimes considered to be hormone or hormone precursor. Vitamin D is involved in promoting normal bone development in body by regulating calcium, phosphorus and minerals. Vitamin D is a secosteroid and sometimes popularly known as the 'sunshine vitamin' because formed in the skin from 7-dehydrocholesterol under the influence of ultraviolet irradiation. Calcitriol is also found in certain food. Fish liver oils, especially code liver oil are good sources of vitamin D. Calcitriol has been used in the management of psoriasis.
Primary Characteristics
Calcitriol is also known as 1, 25 Dihydroxy Vitamin D3 , Vitamin D.
It is of Synthetic origin and belongs to Vitamin D.
It belongs to Vitamin D agonist pharmacological group on the basis of mechanism of action and also classified in Vitamin D Analogue pharmacological group.
Molecular Weight: 416 · Solubility in Water: negligible · Solubility in Alcohol: soluble · Non-proprietary name: Calcitriol.
Pharmacokinetics
Absorption: Calcitriol has an oral bioavailability is 95% (±5%).
Distribution: Calcitriol has a plasma protein binding is >90%.
Elimination: it is metabolised via 35-40%, plasma half-life is 24 hr, renal excretion is <10%.
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Indications
Calcitriol is primarily indicated in conditions like Hypocalcaemia, Hypophosphataemia, Oncogenic hypophosphatemic osteomalacia, Renal tubular osteomalacia, Sporadic hypophosphatemic osteomalacia, Uraemic osteodystrophy, Uremic osteodystrophy, Vitamin D-dependent rickets.
Calcitriol is also indicated for secondary conditions like Neonatal hypocalcemia, Osteomalacia, Osteomalacia in malabsorption syndrome, Osteoporosis, Psoriasis, Rickets in premature infants, X-linked hypophosphataemic osteomalacia.
Contraindications
Calcitriol is contraindicated in conditions like Hypercalcaemia.
Dosage
Calcitriol's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 0.625 mcg | 0.625 mcg | Every 24h | PO | |
| Paediatric Dosage (20kg) | ||||
| 0.03 ug/kg | 0.03 ug/kg | Every 24h | Oral | - |
| Neonatal Dosage (3kg) | ||||
| 0.03 ug/kg | 0.03 ug/kg | Every 24h | Oral | - |
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Calcitriol in overdosage may give rise to further complications which include Urinary calcium stone formation, Urinary calcium stone formation .
Calcitriol produces potentially life-threatening effects which include Depression of CNS, Coma, Ectopic mineralization. Careful monitoring is needed with proper medical management.
The signs and symptoms that are produced after acute overdosage of Calcitriol are Iatrogenic poisoning.
Warnings / Precautions
Interference in Pathology
Calcitriol may interfere in the diagnosis of Assay for plasma Vit. D metabolites (at high doses) .
Available Brands
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Multi-Ingredient Combinations
Storage Conditions
Drug Classification
- 1.27 — Vitamins, minerals, tonics, and other susbstances