Calcitonin

Drug #119

Calcitonin is a single chain peptide hormone with 32 amino acids, secreted by the thyroid gland. A disulfide bond between positions 1 and 7 is essential for its biologic activity. It plays an important role in calcium and bone metabolism, inhibits bone resorption and acts as an antagonist to parathyroid hormone.

← Previous drug Next drug →

Primary Characteristics

It is of Synthetic origin and belongs to Polypeptide.

It belongs to Calcitonin agonist pharmacological group on the basis of mechanism of action and also classified in Antidotes pharmacological group.

Molecular Weight: 3418 · pK_a: - · Solubility in Water: readily soluble in 0.9% NaCl · Non-proprietary name: Calcitonin.

Pharmacokinetics

Distribution: Calcitonin has a volume of distribution is 2.8-11.4 litre. plasma protein binding is low.

Elimination: it is metabolised via Renal, plasma half-life is 2.8-9.1 hr.

Indications

Calcitonin is primarily indicated in conditions like Bone (pagets) disease, Bone pain in neoplastic disease, Hypercalcaemia, Metastatic bone pain, Osteoporosis, Paget's disease of bone, Sudeck's atrophy, Treatment of osteoporosis in post menopausal women.

Contraindications

Calcitonin is contraindicated in conditions like Hypersensitivity.

Dosage

Calcitonin's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
7.14 ug/kg	7.14 ug/kg	Every 24h	SC	-
Paediatric Dosage (20kg)
6 IU/kg	6 IU/kg	Every 24h	Intra Muscular	As Required
6 IU/kg	6 IU/kg	Every 24h	Subcutaneous	As Required
Neonatal Dosage (3kg)
6 IU/kg	6 IU/kg	Every 24h	Intra Muscular	As Required
6 IU/kg	6 IU/kg	Every 24h	Subcutaneous	As Required

Drug Interactions

Unknown2 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Calcitonin in overdosage may give rise to further complications which include Vomiting , Rhinitis , Rhinitis , Abdominal pain, Hypersensitivity reactions , Oedema , Cough , Anaphylactic reactions , Diuresis, Throat Irritation, Musculoskeletal pain, Taste disturbance.

The signs and symptoms that are produced after acute overdosage of Calcitonin are Transient vomiting.

Calcitonin is known to cause more or less tolerable side effects which are usually transient. These include Diarrhea, Dizziness, Fever, Flushing, Headache, Itching, Loss of appetite, Nausea, Rashes .

Warnings / Precautions

Skin testing should be considered before treating with calcitonin, especially for patients with susceptible sensitivity. Because calcitonin is a protein so there is a possibility of systemic allergic reactions, if there is, then stop therapy and manage the conditions accordingly.Ihibit lactation in animals.Use with caution in Renal Impairement patients,avoid unless potential benefits outweight risk.

Available Brands

None recorded.

Storage Conditions

Calcitonin should be stored Aerosol. Inj.

Drug Classification

1.18.14 — Drugs affecting bone metabolism