Gonadotropin
Also known as: Choriogonatrophin, HCG, Chorionic Ganadotropin
Gonadotropin is a hormone. Gonadotropin is used in the treatment of infertility in men and women. It stimulates the ovaries and the testes. Gonadotropin is used in males to stimulate testicular descent or testicular growth and development. In females, Gonadotropin is used in combination with other drugs to induce ovulation. It is a hormone produced by placenta & abtained from the urine of pregnant women.
Primary Characteristics
Gonadotropin is also known as Choriogonatrophin, HCG, Chorionic Ganadotropin.
It is of Natural origin and belongs to Glycoprotein.
It belongs to LH+FSH agonist pharmacological group on the basis of mechanism of action and also classified in Inotropic Agent pharmacological group. It is also classified under Sex Hormones .
Solubility in Water: soluble · Solubility in Alcohol: null · Non-proprietary name: Gonadotropin.
Pharmacokinetics
Absorption: Gonadotropin has an oral bioavailability is 20% (±20%).
Elimination: plasma half-life is 6-11hr & 23-38hr.
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Indications
Gonadotropin is primarily indicated in conditions like Cryptorchidism, Hypogonadotrophic hypogonadism, Induction of ovulation, Infertility.
Contraindications
Gonadotropin is contraindicated in conditions like Prostatic cancer, Hypersensitivity to any component of product.
Dosage
Gonadotropin's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 7500 IU | 7500 IU | — | IM | |
| 3.75 ug/ kg.min | 3.75 ug/ kg.min | — | IV Inf | Initially, As Required |
| 35 ug/ kg.min | 35 ug/ kg.min | — | IV Inf | Maintenance, increased gradually, As Required |
| Paediatric Dosage (20kg) | ||||
| 0 – 0 | — | — | — | Not Recommended in this Age Group |
| Neonatal Dosage (3kg) | ||||
| 0 – 0 | — | — | Not recommended in this age group | |
Drug Interactions
None recorded.
Side Effects
Gonadotropin in overdosage may give rise to further complications which include Ovarian enlargement , Gynacomastia , Shock .
Gonadotropin is known to cause more or less tolerable side effects which are usually transient. These include Acute Abdominal pain, Depression, Edema, Headache, Hypersensitivity reactions, Mood swings, Tinnitus.
Warnings / Precautions
Available Brands
Storage Conditions
Drug Classification
- 1.18.6 — Ovulation stimulants
Manufacturers
Manufacturers of Gonadotropin in Pakistan: