Fosinopril (Na)

Drug #1129

Fosinopril (Na) is ACE inhibitor. It prevents the conversion of certain enzymes in the body. It prevents constriction of blood vessels and lower the blood pressure and makes the heart beat stronger. Fosinopril (Na) is used to treat hypertension (high blood pressure) and heart failure.

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Primary Characteristics

It is of Synthetic origin and belongs to Proline.

It belongs to Angiotensin converting enzyme inhibitor-ACEI pharmacological group on the basis of mechanism of action and also classified in Antihypertensive Agents pharmacological group.

Molecular Weight: 585.6 · Solubility in Water: soluble · Solubility in Alcohol: soluble · Non-proprietary name: Fosinopril (Na).

Pharmacokinetics

Absorption: Fosinopril (Na) has an oral bioavailability is 18% (±18%).

Distribution: Fosinopril (Na) has a plasma protein binding is < 90%.

Elimination: it is metabolised via Intestinal, Hepatic, plasma half-life is 12 hr, renal excretion is 50%.

Indications

Fosinopril (Na) is primarily indicated in conditions like Cardiac failure, Congestive heart failure (adjunct), Gastric acid reduction during anaesthesia, Hypertension.

Contraindications

None recorded.

Dosage

Fosinopril (Na)'s dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
25 mg	25 mg	Every 24h	PO
Paediatric Dosage (20kg)
0 – 0	—	—	—	Not Recommended in this Age Group
Neonatal Dosage (3kg)
No data.

Drug Interactions

Unknown10 interactions

1 interaction

Moderate1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Fosinopril (Na) in overdosage may give rise to further complications which include Viral infections .

Fosinopril (Na) is known to cause more or less tolerable side effects which are usually transient. These include Chest pain, Diarrhea, Edema, Fatigue, Headache, Myalgia, Nausea, Paresthesias, Pharyngitis, Vomiting .

Warnings / Precautions

Fosinopril (Na) should be used with caution in patients with a history of angioedema, high blood levels of potassium, kidney disease or kidney dialysis, salt restrictive diet, liver disease and of any drug allergy. Consult the doctor before using salt substitutes or low salt milk. To avoid dizziness and light-headedness when rising from a seated or lying position, get up slowly. Limit alcohol intake and use caution when exercising or during hot weather as these can aggravate dizziness and lightheadedness. This medication is classified as pregnancy category C and should be used only when clearly needed during the first three months of pregnancy and it is not recommended for use during the last six months of the pregnancy. Caution is advised when this medication is used in children and elderly.

Available Brands

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Single Ingredient

Tabs

10 mg

Storage Conditions

Fosinopril (Na) should be stored Tab.

Drug Classification

1.12.3.3 — ACE inhibitors

Manufacturers

Manufacturers of Fosinopril (Na) in Pakistan:

Akson GSK