DrugInfoSys

Furazolidone

Drug #1130

Furazolidone is antibacterial agent, used in the treatment of bacterial diarrhea and gastro-enteritis. It may also be useful in treating traveler's diarrhea, typhoid fever, cholera and salmonella infections.

Primary Characteristics

It is of Semi Synthetic origin and belongs to Polysaccharide.

It belongs to Antibiotic (Prokaryote DNA) pharmacological group on the basis of mechanism of action. It is also classified under Antiviral Agents .

Molecular Weight: 225.2 · Solubility in Water: very slight · Solubility in Alcohol: very slight · Non-proprietary name: Typhoid Vaccine.

Molecular structure of Furazolidone

Pharmacokinetics

Elimination: it is metabolised via extensive in intestine.

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Indications

Contraindications

Furazolidone is contraindicated in conditions like G6pd deficiency.

Dosage

Furazolidone's dosage details are as follows:

DoseSingle DoseFrequencyRouteInstructions
Adult Dosage
37.5 mg37.5 mgEvery 6hPOFor 7-10 Days
Paediatric Dosage (20kg)
1.25 mg/kg1.25 mg/kgEvery 6hOral For Paeds of all ages
Neonatal Dosage (3kg)
No data.

Drug Interactions

Unknown2 interactions
3 interactions
Major14 interactions
Moderate2 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Furazolidone in overdosage may give rise to further complications which include Hepatotoxicity , Agranulocytosis , Hepatotoxicity , Hacmolytic Anemia, Acute pulmonary reactions.

Furazolidone is known to cause more or less tolerable side effects which are usually transient. These include Angioedema, Arthralgia, Darkening of urine, dizziness, Drowsiness, Fever, Headache, Hypotension , Malaise, Nausea, Redness, Skin rashes, Urticaria, Vomiting .

Warnings / Precautions

Furazolidone should be used with caution in patients with medical history, especially of blood disorders, glucose-6-phosphate dehydrogenase (G6PD) deficiency or allergies, especially of drug allergies. Avoid intake of alcohol during therapy and for 4 days after taking this medication. The following are among the foods and beverages to be avoided while taking this medication and for 2 weeks after stop. These foods interact with monoamino oxidase (MAO) inhibitors causing severe headache and increased blood pressure and could lead to a medical emergency, so use with caution while taking meat, fish, pickled herring, liver, dry sausage, meats prepared with tenderizer, yogurt, sour cream, cheese, beverages, avoid excessive amounts of caffeine containing colas, coffee and tea, fruits or vegetables, bananas, figs, raisins, broad beans, yeast extract, soya sauce, large amounts of chocolate. This medication should be used only if clearly needed during pregnancy or lactation. Infants less than one month old should not receive this drug.The drug also inhibit some enzymes including monoamine oxidase. The urine of the patient on furazolidone may be coloured a dark yellow or brown ; this results from the presence of metabolites and is not harmful.

Available Brands

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Single Ingredient

Multi-Ingredient Combinations

Storage Conditions

Furazolidone should be stored Tab. Syrup.

Drug Classification

  1. 1.17.7.2Antidiarrheals

Manufacturers