Fosfomycin
Fosfomycin is analog of phosphoenolpyruvate. Fosfomycin is structurally unrelated to any other antimicrobial agent. Fosfomycin is active against both gram negative and gram positive bacteria. It has been used successfully in the treatment of pneumonia, UTIs, bronchitis, and other respiratory tract infections. Antibiotics require constant drug level in body for therapeutic effect. This is achieved by taking the drug at regular interval of time throughout the day and night as prescribed. Fosfomycin is important to take the drug for the full time period as prescribed. If you discontinue the drug it may result in ineffective treatment.
Primary Characteristics
Fosfomycin is also known as Fosfomycin Calcium.
It is of Semi Synthetic origin and belongs to Phosphoric Acid.
It belongs to Antibiotic (Cell Wall) pharmacological group on the basis of mechanism of action.
Molecular Weight: 138.1 · Solubility in Water: null · Solubility in Alcohol: null · Non-proprietary name: Fosfomycin.
Pharmacokinetics
Distribution: Fosfomycin has a volume of distribution is 2 l/kg. plasma protein binding is < 3%.
Elimination: plasma half-life is 4-8 hr.
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Indications
Fosfomycin is primarily indicated in conditions like Urinary tract infection.
Contraindications
Fosfomycin is contraindicated in conditions like Hypersensitivity to the drug.
Dosage
Fosfomycin's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 1 g | 1 g | Every 8h | IM | |
| 2.5 g | 2.5 g | Every 8h | IV | |
| 3 g | 3 g | — | PO | As a single dose or 2 div.doses. |
| Paediatric Dosage (20kg) | ||||
| 50 mg/kg | 50 mg/kg | Every 8h | Intra Muscular | - |
| 150 mg/kg | 150 mg/kg | Every 8h | Intra Venous | - |
| 25 mg/kg | 25 mg/kg | Every 6h | Oral | - |
| Neonatal Dosage (3kg) | ||||
| 31.25 mg/kg | 31.25 mg/kg | Every 12h | Intramuscular | |
| 250 mg/kg | 250 mg/kg | Every 24h | Intravenous | |
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Fosfomycin is known to cause more or less tolerable side effects which are usually transient. These include Asthenia , Diarrhea, Dizziness, Headache, Increased intracranial pressure, Nausea, Vaginitis.
Warnings / Precautions
Available Brands
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Single Ingredient
Storage Conditions
Drug Classification
- 1.6.2.1.4 — Other inhibitors of cell wall synthesis