Formestane - Drug Monograph | DrugInfoSys ODIS

Primary Characteristics

It is of origin and belongs to Androstenedione .

It is classified in Antineoplastic Agent, Aromatase Inhibitor pharmacological group.

Molecular Weight: 302.4 · Solubility in Water: null · Solubility in Alcohol: null · Non-proprietary name: Formestane.

Pharmacokinetics

Distribution: Formestane has a volume of distribution is . plasma protein binding is 85% .

Elimination: it is metabolised via , plasma half-life is , renal excretion is 1% .

Indications

Formestane is primarily indicated in conditions like Breast cancer.

Contraindications

Formestane is contraindicated in conditions like Premenopausal breast cancer.

Dosage

Formestane's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
3.571 mg/kg	3.571 mg/kg	—	IM	Fortnightly
Paediatric Dosage (20kg)
0 – 0	—	—	—	Not Recommended in this Age Group
Neonatal Dosage (3kg)
0 – 0	—	—		Not recommended in this age group

Drug Interactions

Unknown1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Formestane in overdosage may give rise to further complications which include Vaginal bleeding .

Formestane produces potentially life-threatening effects which include Anaphylaxis . Careful monitoring is needed with proper medical management.

Formestane is known to cause more or less tolerable side effects which are usually transient. These include Arthralgia, Bone pain, Hot flushes, Muscle cramps, Skin reactions.

Warnings / Precautions

Formestane is not recommended for use during pregnancy or lactation. Immunosuppressent drug should not be given, where possible, to patients with acute infection, dosage reduction or withdrawal should be considered if infection develops, until the infection has been controlled. Blood counts and measurement of hemoglobin concentration should be carried out routinely, it helps to predict the onset of bone marrow depression. It must be handled with great care and avoid contact with skin and eyes, and should not be inhaled.

Available Brands

None recorded.

Storage Conditions

Formestane should be stored Inj (reconstituted susp). Vial.

Drug Classification

1.8.3 — Hormones and antihormones