Fluconazole

Also known as: diflucan, triflucan,

Drug #1120

Fluconazole is antifungal agent. Fluconazole is a substituted triazole derivetive. The requirement for intravenous administration and the toxicity of the older antifungal agents created a need for antifungal agents with a better therapeutic profile. The relatively non-toxic oral azole medications represent the first major advance in this direction. Since their introduction in the 1980s, these medications have played an increasingly important role in the systemic therapy of fungal disease.

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Primary Characteristics

Fluconazole is also known as diflucan, triflucan, .

It is of Synthetic origin and belongs to Triazol.

It is classified in Antifungal Agent, Parental pharmacological group.

Molecular Weight: 306.3 · pK_a: 2.03 · Solubility in Water: Slightly Soluble · Solubility in Alcohol: sparingly soluble · Non-proprietary name: Fluconazole.

Pharmacokinetics

Absorption: Fluconazole has an oral bioavailability is 45% (±45%), pre-systemic (first-pass) metabolism accounts for 2.5% (±2.5%).

Distribution: Fluconazole has a volume of distribution is 0.55-0.651 l/kg. plasma protein binding is 11 - 12 %.

Elimination: it is metabolised via 11%, plasma half-life is 25 - 30 hr, renal excretion is 80 %.

Indications

Fluconazole is primarily indicated in conditions like Adjunctive therapy without valproate, Candidiasis, Cryptcoccal meningitis, Fungal infection, Neurogenic bladder, Oropharangeal candidiasis, Parkinsonism, Pityriasis versicolor, Vaginal infections.

Fluconazole is also indicated for secondary conditions like Bone marrow transplantation, Cryptococcal infections including meningitis, Esophagitis, Urinary tract infection.

Contraindications

None recorded.

Dosage

Fluconazole's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
450 mg /day	450 mg /day	Every 24h	IV	for Mucocutaneous candidiasis
350 mg	350 mg	Every 24h	PO,IV	Maintenance, As Required
400 mg	400 mg	—	PO,IV	Initially for Once
Paediatric Dosage (20kg)
1.5 mg/kg	1.5 mg/kg	Every 24h	Slow IV	-
Neonatal Dosage (3kg)
1.5 mg/kg	1.5 mg/kg	Every 24h	Slow IV	-

Drug Interactions

Unknown10 interactions

12 interactions

Major3 interactions

Minor2 interactions

Moderate8 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Fluconazole in overdosage may give rise to further complications which include Alopecia , Thrombocytopenia , Elevated alkaline phosphatase concentration, Eelvated hepatic enzymes , Hyperlipidemia, Elevated alkaline phosphatase concentration.

Fluconazole produces potentially life-threatening effects which include Hepatic necrosis, Death, Severe skin reactions in AIDS. Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Fluconazole are Hallucinations , Paranoid psychosis.

Fluconazole is known to cause more or less tolerable side effects which are usually transient. These include Abdominal pain, Anaphylaxis, Diarrhea, Dizziness, Headache, Hypokalemia , Leucopenia, Nausea, Pallor, Rashes , Vomiting .

Warnings / Precautions

Fluconazol should be used with caution in patients with liver disease, kidney disease or of any drug allergy. This medication should be used only when clearly needed during pregnancy. Avoid fluconazole during lactation.childern not recommended under one year.Dose adjusted in renal impairment.

Interference in Pathology

Fluconazole may interfere in the diagnosis of Increased Alkaline Phosphatase , Bilirubin (increased level).

Available Brands

Click on a strength to view available brands.

Single Ingredient

Caps

Inf

Inj

Susp

Tabs

Storage Conditions

Fluconazole should be stored Tab, Oral Susp.

Drug Classification

1.6.3 — Antifungal drugs