Finasteride
Finasteride used to treat prostatic hypertrophy (enlargement of prostate gland) and to treat male pattern hair loss and is to be used only by adult men.
Primary Characteristics
It is of Synthetic origin and belongs to Azasteroid.
It belongs to Androgen antagonist pharmacological group on the basis of mechanism of action and also classified in Anti Allergic Agent pharmacological group.
Molecular Weight: 372.5 · pKa: 15.91 · Solubility in Water: Insoluble · Solubility in Alcohol: Freely Soluble · Non-proprietary name: Finasteride · pH: 6.8.
Pharmacokinetics
Absorption: Finasteride has an oral bioavailability is 50% (±50%).
Distribution: Finasteride has a volume of distribution is 76 liters. plasma protein binding is 93 %.
Elimination: it is metabolised via Liver, plasma half-life is 6 hr, renal excretion is 39 %.
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Indications
Finasteride is primarily indicated in conditions like Alopecia, Benign prostatic hyperplasia, Male-pattern baldness in men, Prostatic cancer.
Finasteride is also indicated for secondary conditions like Hair loss.
Contraindications
Finasteride is contraindicated in conditions like Obstructive uropathy.
Dosage
Finasteride's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 1 mg | 1 mg | — | PO | For male Pattern baldners for 3 months. |
| 5 mg | 5 mg | — | PO | As Required |
| Paediatric Dosage (20kg) | ||||
| 0 – 0 | — | — | — | Not Recommended in this Age Group |
| Neonatal Dosage (3kg) | ||||
| 0 – 0 | — | — | — | Not Recommended in this Age Group |
Drug Interactions
None recorded.
Side Effects
Finasteride in overdosage may give rise to further complications which include Impotence , Decreased libido , Decreased ejaculation , Testicular pain, Tenderness & Enlargement of breast.
Warnings / Precautions
Available Brands
Storage Conditions
Drug Classification
- 1.29 — Drugs used in renal, bladder, and prostatic disorders