Fexofenadine

Drug #1116

Fexofenadine (HCl) is antihistaminic agent. Histamine mediates allergic and inflammatory reactions. Fexofenadine (HCl) is used to relieve allergy symptoms such as watery, itchy, red eyes, sneezing, runny nose etc.

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Primary Characteristics

Fexofenadine is also known as Fexofenadine (Hcl).

It belongs to piperadine.

It belongs to H1-antagonist pharmacological group on the basis of mechanism of action.

Molecular Weight: 501.66 · Solubility in Water: slightly soluble · Solubility in Alcohol: freely soluble · Non-proprietary name: Fexofenadine.

Pharmacokinetics

Absorption: Fexofenadine has an pre-systemic (first-pass) metabolism accounts for 2.5% (±2.5%).

Distribution: Fexofenadine has a plasma protein binding is 70%.

Elimination: it is metabolised via Gut, plasma half-life is 14.4hr, renal excretion is 11%.

Indications

Fexofenadine is primarily indicated in conditions like Allergy, Chronic idiopathic urticaria, Cytotoxic-induced neutropenia, Hay fever, Rhinitis, Seasonal allergic rhinitis, Symptomatic relief of seasonal allergic rhinitis, Urticaria.

Fexofenadine is also indicated for secondary conditions like Runny nose, Sneezing.

Contraindications

None recorded.

Dosage

Fexofenadine's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
120 – 180 mg	—	Every 12h	PO	should be given in two divided doses. reduce the dose by half in patients with renal impairment
Paediatric Dosage (20kg)
30 – 0 mg	—	Every 12h		Not Recommended in this Age Group
Neonatal Dosage (3kg)
0 – 0	—	—		Not recommended in this age group

Drug Interactions

Unknown2 interactions

4 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Fexofenadine in overdosage may give rise to further complications which include Viral infections .

The signs and symptoms that are produced after acute overdosage of Fexofenadine are Convulsions , Ventricular arrhythmias, Excitement, Ataxia, Cardiovascular collapse, Cardiorespiratory collapse, Coma, Hallucinations , Sedation , Psychosis , Tremor, Hyperreflexia .

Fexofenadine is known to cause more or less tolerable side effects which are usually transient. These include Blood dyscrasias, CNS depression, Cold & flu, Diarrhea, Dizziness, Drowsiness, Dysmenorrhea, Hair loss, Headache, Hypersensitivity reactions, Hypotension , Increased intracranial pressure, Nausea, psychomotor impairment, Tinnitus, Vomiting .

Warnings / Precautions

Fexofenadine should be used with caution in patients with kidney disease or any allergy, hepatic impairment. Do not take this medication for several days before any allergy testing since test results can be affected. Although drowsiness is uncommon at usual doses under normal circumstances, be aware that this medication may have such effects, before engaging in activities requiring alertness. This medication should be used only if clearly needed during pregnancy or lactation. Caution is advised when this drug is used in the elderly patients.

Available Brands

Click on a strength to view available brands.

Single Ingredient

Caps

120 mg 20 mg 60 mg

Susp

30 mg/5ml

Tabs

120 mg 180 mg 60 mg 80 mg

Multi-Ingredient Combinations

Tabs

60 mg

Storage Conditions

Fexofenadine should be stored Caps.

Drug Classification

1.3 — Anti-allergics (Antihistamines) and drugs used in anaphylaxis