Buserelin (Acetate)
Buserelin (Acetate) is analogue of gonadotrophin-releasing hormone that suppresses androgen production by testes. Buserelin (Acetate) is used in the treatment of carcinoma of prostate and endometriosis.
Primary Characteristics
It is of Synthetic origin and belongs to Peptide Hormone.
Molecular Weight: 1239.4 · Solubility in Water: soluble · Solubility in Alcohol: null · Non-proprietary name: Buserelin (Acetate).
Pharmacokinetics
Elimination: plasma half-life is 3-6 hr, renal excretion is major.
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Indications
Buserelin (Acetate) is primarily indicated in conditions like Endometriosis, Fibroids, In-vitro fertilization programmes, Mobilisation of peripheral blood progenitor cells, Pituitary desensitisation, Polycystic ovary syndrome, Precocious puberty, Prostatic cancer.
Buserelin (Acetate) is also indicated for secondary conditions like Advanced prostate cancer.
Contraindications
None recorded.
Dosage
Buserelin (Acetate)'s dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 100 mcg | 100 mcg | Every 4h | Nasal | For 6 Months |
| Paediatric Dosage (20kg) | ||||
| 0 – 0 | — | — | — | Rerely used in this Age Group |
| Neonatal Dosage (3kg) | ||||
| 0 – 0 | — | — | Not recommended in this age group | |
Drug Interactions
None recorded.
Side Effects
Buserelin (Acetate) in overdosage may give rise to further complications which include Histological changes in testis .
Buserelin (Acetate) is known to cause more or less tolerable side effects which are usually transient. These include Hot flushes, Loss of libido, Menopausal symptoms.
Warnings / Precautions
Available Brands
None recorded.
Storage Conditions
Drug Classification
- 1.18.6 — Ovulation stimulants