Buprenorphine (HCl)
Buprenorphine (HCl) is a synthetic derivative of thebaine. Buprenorphine (HCl) is narcotic analgesic. Buprenorphine (HCl) is used to relieve the moderate to severe pain and as an adjunct to anesthesia.
Primary Characteristics
It is of Synthetic origin and belongs to Opiate.
It belongs to OPIATE agonist pharmacological group on the basis of mechanism of action and also classified in Analgesic-Narcotic pharmacological group. It is also classified under Analgesics and Anti-inflammatory Agents .
Molecular Weight: 504 · pKa: 8.42, 9.92 · Solubility in Alcohol: 1 in 24 · Non-proprietary name: Buprenorphine (HCl).
Pharmacokinetics
Distribution: Buprenorphine (HCl) has a volume of distribution is 2.5 l/kg. plasma protein binding is 96%.
Elimination: it is metabolised via Hepatic, plasma half-life is 4-6 hr, renal excretion is Negligible.
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Indications
Buprenorphine (HCl) is primarily indicated in conditions like Adjunct in the treatment of opiod dependence, Adjunct to prevent relapse, Advanced breast cancer in postmenopausal women, All forms of epilepsy, Cocaine withdrawal, Moderate to severe acute pain, Moderate to severe chronic pain, Moderate to severe pain, Myoclonus, Opioid agonist dependence, Post operative analgesia.
Contraindications
Buprenorphine (HCl) is contraindicated in conditions like Phaeochromocytoma, Respiratory disease, Paralytic ileus, Head injury, Atrophic oral candidiasis associated with dentures.
Dosage
Buprenorphine (HCl)'s dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 0.45 mg | 0.45 mg | Every 8h | IV,IM | |
| 0.3 mg | 0.3 mg | Every 8h | PO | |
| Paediatric Dosage (20kg) | ||||
| 6 ug/kg | 6 ug/kg | Every 8h | Intra Muscular | - |
| 6 ug/kg | 6 ug/kg | Every 8h | Intra Venous | - |
| Neonatal Dosage (3kg) | ||||
| 6 ug/kg | 6 ug/kg | Every 8h | Intramuscular | |
| 6 ug/kg | 6 ug/kg | Every 8h | Intravenous | |
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Buprenorphine (HCl) in overdosage may give rise to further complications which include Hallucinations .
Buprenorphine (HCl) produces potentially life-threatening effects which include Respiratory depression. Careful monitoring is needed with proper medical management.
Buprenorphine (HCl) is known to cause more or less tolerable side effects which are usually transient. These include Constipation , Dizziness, Headache, Nausea, Sweating , Vertigo, Vomiting .
Warnings / Precautions
Available Brands
Storage Conditions
Drug Classification
- 1.2.2 — Opioid analgesics