Buspirone (HCl)
Buspirone (HCl) is anxiolytic agent and a 5-HT 1 agonist. Buspirone (HCl) is a new non-benzodiazepine. It relieves nervousness, anxiety. Unlike benzodiazepines the drug has less side effects.
Primary Characteristics
It is of Synthetic origin and belongs to Pyrimidinyl piperazinyl decane.
It belongs to 5HT-1A antagonist pharmacological group on the basis of mechanism of action and also classified in Antianxiety Agent pharmacological group. It is also classified under Psychotherapeutic Drugs .
Molecular Weight: 422 · pKa: 1.22, 7.32 · Solubility in Water: 1 in 1 · Solubility in Alcohol: 1 in 50 · Non-proprietary name: Buspirone (HCl).
Pharmacokinetics
Absorption: Buspirone (HCl) has an oral bioavailability is 100%, pre-systemic (first-pass) metabolism accounts for 96%.
Distribution: Buspirone (HCl) has a volume of distribution is 5.3 l/kg. plasma protein binding is 95%.
Elimination: it is metabolised via extensive via liver, plasma half-life is 2-11hr, renal excretion is 65%.
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Indications
Buspirone (HCl) is primarily indicated in conditions like Generalized anxiety disorder, Non-specific anxiety symptoms, Suppression of transplant rejection.
Contraindications
Buspirone (HCl) is contraindicated in conditions like Epilepsy, Renal impairment, Hepatic impairment, Hypersensitivity.
Dosage
Buspirone (HCl)'s dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 5 mg | 5 mg | Every 8h | PO | Increased by 5 mg every 2-3 days. |
| Paediatric Dosage (20kg) | ||||
| 0 – 0 | — | — | — | Not Recommended in this Age Group |
| Neonatal Dosage (3kg) | ||||
| 0 – 0 | — | — | Not recommended in this age group | |
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
The signs and symptoms that are produced after acute overdosage of Buspirone (HCl) are Nausea, Miosis, Gastric distress, Dizziness, Vomiting, Drowsiness.
Buspirone (HCl) is known to cause more or less tolerable side effects which are usually transient. These include Dizziness, Fatigue, Gastric complaints, Headache, Sleeplessness, Uneasiness, Vomiting .
Warnings / Precautions
Available Brands
Storage Conditions
Drug Classification
- 1.24.3 — Drugs used in anxiety and sleep disorders