Zolpidem (Tartrate)
Zolpidem (Tartrate) is a non-benzodiazepine sedative-hypnotic for the short-term treatment of insomnia. Although chemically unrelated to other hypnotics such as the benzodiazepines or barbiturates, zolpidem does share some pharmacological actions with these drugs. Unlike the benzodiazepines, zolpidem produces muscle relaxation and anticonvulsant effects only at doses much higher than the hypnotic dose. Zolpidem has a short half-life and no active metabolites. Therefore, a next-day "hangover" effect and CNS depression are less for zolpidem than the barbiturates. Treatment of insomnia with zolpidem should be restricted to a period of 7-10 days. Zolpidem received FDA approval in 1993.
Primary Characteristics
It belongs to Imidazopyridine.
It belongs to Chloride Channel opener (Gaba operated) pharmacological group on the basis of mechanism of action. It is also classified under Sedatives and Hypnotics .
Molecular Weight: 764.9 · Solubility in Water: slightly soluble · Solubility in Alcohol: sparingly soluble · Non-proprietary name: Zolpidem (Tartrate).
Pharmacokinetics
Distribution: Zolpidem (Tartrate) has a plasma protein binding is 92 %.
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Indications
Zolpidem (Tartrate) is primarily indicated in conditions like Insomnia, Nausea, vertigo, labyrinthine disorders.
Contraindications
Zolpidem (Tartrate) is contraindicated in conditions like Myasthenia gravis, Psychosis, Pulmonary insufficiency, Respiratory depression, Sleep apnea syndrome.
Dosage
Zolpidem (Tartrate)'s dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 10 mg | 10 mg | Every 24h | PO | |
| Paediatric Dosage (20kg) | ||||
| 0 – 0 | — | — | Not recommended in this age group | |
| Neonatal Dosage (3kg) | ||||
| 0 – 0 | — | — | Not recommended in this age group | |
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Zolpidem (Tartrate) in overdosage may give rise to further complications which include Dementia .
Zolpidem (Tartrate) is known to cause more or less tolerable side effects which are usually transient. These include Confusion, Depression, Dizziness, Drowsiness, GI upset, Headache, Tremor.
Warnings / Precautions
Available Brands
Storage Conditions
Drug Classification
- 1.24.3 — Drugs used in anxiety and sleep disorders