Zolmitriptan
Zolmitriptan is a selective serotonin (5-HT) antagonist, used in the treatment of acute migraine attack but it does not prevent migraine attack.
Primary Characteristics
It is of Synthetic origin and belongs to Aminoindole.
It belongs to 5HT-1 agonist pharmacological group on the basis of mechanism of action and also classified in Serotonin 5HT1D Receptor Agonist pharmacological group. It is also classified under Antimigraine .
Molecular Weight: 287.4 · Solubility in Water: readily soluble · Solubility in Alcohol: null · Non-proprietary name: Zolmitriptan.
Pharmacokinetics
Distribution: Zolmitriptan has a volume of distribution is 7 l/kg. plasma protein binding is 25%.
Elimination: plasma half-life is 2.8 - 3.7 hr, renal excretion is 60 - 65%.
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Indications
Zolmitriptan is primarily indicated in conditions like Migraine, Treatment of acute migraine attacks.
Contraindications
Zolmitriptan is contraindicated in conditions like Hypertension, Prinzmetal's angina.
Dosage
Zolmitriptan's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 2.5 mg | 2.5 mg | — | PO | As Required |
| Paediatric Dosage (20kg) | ||||
| 0 – 0 | — | — | Not recommended in this age group | |
| Neonatal Dosage (3kg) | ||||
| 0 – 0 | — | — | Not recommended in this age group | |
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Zolmitriptan in overdosage may give rise to further complications which include Myocardial infarction , Angina .
Zolmitriptan is known to cause more or less tolerable side effects which are usually transient. These include Asthenia , Dizziness, Heaviness, Muscle weakness, Nausea, SomnolenceX, Warmth feeling.
Warnings / Precautions
Available Brands
Storage Conditions
Drug Classification
- 1.7.1 — Acute migraine attack