Venlafaxine (HCl)
Venlafaxine (HCl) is oral antidepressant with novel structure. Venlafaxine (HCl) is designated as (+/-)-1-[a-[(dimethylamino) methyl]-p-methoxybenzyl] cyclohexanol. Venlafaxine (HCl) is chemically unrelated to other available antidepressant agents, but actions are similar to tricyclic antidepressants (e.g amitriptyline). It inhibits the neuronal uptake of the neurotransmitters, noradrenaline and serotonin but does not exhibit anticholinergic effects. Therefore less likely to cause cardiac effects or convulsions during therapy or in case of overdosage.
Primary Characteristics
It belongs to Phenylethylamine.
It is classified in Antidepressant pharmacological group. It is also classified under Psychotherapeutic Drugs .
Molecular Weight: 313.9 · Solubility in Water: 572 mg/ml · Solubility in Alcohol: null · Non-proprietary name: Venlafaxine (HCl).
Pharmacokinetics
Absorption: Venlafaxine (HCl) has an oral bioavailability is 27.5% (±17.5%).
Distribution: Venlafaxine (HCl) has a volume of distribution is 7.5 +/- 3.7 l/kg. plasma protein binding is 27 %.
Elimination: it is metabolised via Hepatic, plasma half-life is 2.1 - 2.4 hr, renal excretion is 87 %.
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Indications
Venlafaxine (HCl) is primarily indicated in conditions like Anxiety, Depression, Depressive illness, Severe depression, Treatment of osteoporosis in post menopausal women.
Contraindications
None recorded.
Dosage
Venlafaxine (HCl)'s dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 75 mg | 75 mg | — | PO | Usually in 2-3 divided doses. Dose may be increased to 150 mg after several weeks if necessary. |
| Paediatric Dosage (20kg) | ||||
| 0 – 0 | — | — | Not recommended in this age group | |
| Neonatal Dosage (3kg) | ||||
| 0 – 0 | — | — | Not recommended in this age group | |
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Venlafaxine (HCl) in overdosage may give rise to further complications which include Migraine , Hypertension , Palpitation .
Venlafaxine (HCl) is known to cause more or less tolerable side effects which are usually transient. These include Abdominal pain, Anorexia , Dizziness, Dry mouth, Flatulence, Flu like syndrome, Headache, Increased intracranial pressure, Migraine , Neck pain, Vomiting , Weight gain, Weight loss.
Warnings / Precautions
Available Brands
Storage Conditions
Drug Classification
- 1.24.2.1 — Drugs used in depression