Valsartan
Valsartan belongs to a new and rapidly growing group of drugs known as angiotensin receptor antagonists. itsimilar to losartan. Valsartan antagonizes angiotensin II at the AT1 receptor subtype. Two angiotensin II receptors, AT1 and AT 2, have been identified. Angiotensin II is the primary vasoactive hormone of the renin-angiontensin system and plays an important role in the pathophysiology of hypertension and congestive heart failure. Valsartan is currently approved as an oral antihypertensive agent, either alone or in combination with other antihypertensive agents. Valsartan reduces left ventricular hypertrophy, although the clinical benefValsartan associated with reducing LV hypertrophy is not well established. Unlike losartan, Valsartan has no effect on serum uric acid. Valsartan was FDA approved for the treatment of hypertension on 23rd december 1996.
Primary Characteristics
It is of Synthetic origin and belongs to Valine.
It is classified in Antihypertensive Agents pharmacological group.
Molecular Weight: 435.5 · Solubility in Water: slightly · Solubility in Alcohol: soluble · Non-proprietary name: Valsartan.
Pharmacokinetics
Absorption: Valsartan has an oral bioavailability is 23% (±7%).
Distribution: Valsartan has a volume of distribution is 17 litre. plasma protein binding is 94 - 97 %.
Elimination: it is metabolised via 9% (Hepatic), plasma half-life is 6 - 9 hr, renal excretion is 13 %.
Advertisement
Indications
Valsartan is primarily indicated in conditions like Chronic congestive heart failure, Hypertension, Myocardial infarction.
Contraindications
None recorded.
Dosage
Valsartan's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 120 mg | 120 mg | Every 24h | PO | |
| Paediatric Dosage (20kg) | ||||
| 0 – 0 | — | — | Not recommended in this age group | |
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Valsartan in overdosage may give rise to further complications which include Hyperkalemia , Anemia , Angioedema , Azotemia.
Valsartan is known to cause more or less tolerable side effects which are usually transient. These include Abdominal pain, Cough , Dizziness, Fatigue, Headache.
Warnings / Precautions
Available Brands
Storage Conditions
Drug Classification
- 1.12.3.4 — Angiotensin II receptor anatgonists