Tiropramide (HCl)
Tiropramide (HCl) used as an antispasmodic. itusually given by mouth, but can also be given parentrally or rectally.
Primary Characteristics
It is of origin and belongs to Amide .
It belongs to Cholinergic muscarinic antagonist pharmacological group on the basis of mechanism of action and also classified in Antispasmodic Agent pharmacological group. It is also classified under Gastrointestinal Anticholinergics/Antispasmodics .
Molecular Weight: 504.1 · Solubility in Water: null · Solubility in Alcohol: null · Non-proprietary name: Tiropramide HCl.
Pharmacokinetics
Distribution: Tiropramide (HCl) has a volume of distribution is . plasma protein binding is .
Elimination: it is metabolised via , plasma half-life is , renal excretion is .
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Indications
Tiropramide (HCl) is primarily indicated in conditions like Dysmenorrhoea, Irritable bladder, Spasticity.
Contraindications
Tiropramide (HCl) is contraindicated in conditions like Mega colon, Circulatory collapse, GI obstruction.
Dosage
Tiropramide (HCl)'s dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 75 mg | 75 mg | Every 24h | IV,IM | |
| 125 mg | 125 mg | Every 12h | PO | |
| Paediatric Dosage (20kg) | ||||
| 0 – 0 | — | — | Not recommended in this age group | |
| Neonatal Dosage (3kg) | ||||
| 0 – 0 | — | — | Not recommended in this age group | |
Drug Interactions
None recorded.
Side Effects
None recorded.
Available Brands
Storage Conditions
Drug Classification
- 1.17.5 — Antispasmodics
Manufacturers
Manufacturers of Tiropramide (HCl) in Pakistan: