Tioconazole

Drug #1074

Tioconazole is antifungal agent, with actions and uses similar to miconazole. Tioconazole is used topically to treat fungal infections of nails, also effective in candidiasis and various dermatophytic infections.

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Primary Characteristics

It belongs to Imidazole.

It is classified in Antifungals pharmacological group.

Molecular Weight: 387.7 · Solubility in Water: null · Solubility in Alcohol: null · Non-proprietary name: Tioconazole.

Pharmacokinetics

Elimination: plasma half-life is 21- 24 hr, renal excretion is 1 %.

Indications

Tioconazole is primarily indicated in conditions like Dermatophytic infections, Mycoses, Pityriasis, Superficial candidiasis, Vaginal infections.

Contraindications

None recorded.

Dosage

Tioconazole's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
1 %	1 %	Every 12h	Topical	For 6 Weeks to 1 Year
Paediatric Dosage (20kg)
1 %	1 %	Every 12h	Topical	For 6 Weeks to 1 Year
Neonatal Dosage (3kg)
1 %	1 %	Every 12h	Topical	For 6 Weeks to 1 Year

Drug Interactions

None recorded.

Side Effects

Tioconazole is known to cause more or less tolerable side effects which are usually transient. These include Burning, Erythema, Itching.

Warnings / Precautions

Tioconazol should be used with caution in patients with medical history including use of latex diaphragms or condoms and of any allergy. It should be used only when clearly needed during pregnancy. The ointment base of this drug can weaken latex. Therefore, do not use latex condoms or diaphragms for 3 days after using this medication.

Available Brands

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Single Ingredient

Cream

1 %w/w

Storage Conditions

Tioconazole should be stored Gel.

Drug Classification

1.13.1 — Antifungals, topical

Manufacturers

Manufacturers of Tioconazole in Pakistan:

Pfizer