Budesonide

Drug #107

Budesonide is a synthetic corticosteroid. Budesonide is used by inhalation in moderate to severe asthma that is unresponsive to other drugs. Inhaled corticosteroid works as an anti-inflammatory agent in the nasal mucosa to treat symptoms of allergies including nasal congestion, itching, runny nose or sneezing.

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Primary Characteristics

It is of Synthetic origin and belongs to Corticosteroid.

It belongs to Glucocorticoid agonist pharmacological group on the basis of mechanism of action and also classified in Corticosteroid Nasal pharmacological group.

Molecular Weight: 430.5 · pK_a: not relevant · Solubility in Water: 1 in 10000 · Solubility in Alcohol: 1 in 30 · Non-proprietary name: Budesonide.

Pharmacokinetics

Absorption: Budesonide has an oral bioavailability is 100%, pre-systemic (first-pass) metabolism accounts for 90%.

Distribution: Budesonide has a volume of distribution is 43 l/kg. plasma protein binding is 86-90%.

Elimination: it is metabolised via hepatic, plasma half-life is 2-3 hr.

Indications

Budesonide is primarily indicated in conditions like Asthma, Crohn's disease, Dermatosis, Eczema, Rhinitis, Ulcerative colitis.

Budesonide is also indicated for secondary conditions like Less severe asthma, Liver transplant, Ventricular fibrillation, pulseless ventricular tachycardia.

Contraindications

Budesonide is contraindicated in conditions like Diabetes mellitus, Glucoma, Hypertension, Osteoporosis, Pulmonary TB, Fungal or viral respiratory infection.

Dosage

Budesonide's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
500 mcg	500 mcg	Every 12h	Inhalation
Paediatric Dosage (20kg)
12.5 ug/kg	12.5 ug/kg	Every 12h	Inhalation	-
Neonatal Dosage (3kg)
9.375 ug/kg	9.375 ug/kg	Every 12h	Inhalation

Drug Interactions

Unknown2 interactions

1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Budesonide in overdosage may give rise to further complications which include Osteoporosis , Ocular hypertension , Cushing like features , Suppression of adrenal function, Peptic ulceration .

Budesonide is known to cause more or less tolerable side effects which are usually transient. These include Agitation , Candidiasis , Coughing, GI disturbance, Insomnia, Irritation of throat, Skin reactions.

Warnings / Precautions

Budesonide should be used with caution in patients with medical history including all illnesses, infections, recent exposures to contagious diseases (e.g. chicken pox), glaucoma, cataracts or any allergies, especially of any drug allergy. If patients are switching or have switched within the last 9 months from an oral corticosteroid to an inhaled one and experience loss of appetite, nausea, vomiting, unusual tiredness, headache, fever, dizziness, joint and muscle pain or weight loss, so should contact the doctor, there may need to increase dose of the oral corticosteroid temporarily or start taking it again. Children and teenagers should be monitored for proper growth patterns while using any corticosteroid medicine. This medication should be used only when clearly needed during pregnancy or lactation.

Available Brands

Click on a strength to view available brands.

Single Ingredient

Inhaler

100 mcg 200 mcg 200 mcg/actu 50 mcg/actu

Multi-Ingredient Combinations

Inhaler

100 mg 200 mg

Rota Caps

100 mcg 200 mcg 400 mcg

Storage Conditions

Budesonide should be stored Aerosol.

Drug Classification

1.25.1.2 — Inhalants

Manufacturers

Manufacturers of Budesonide in Pakistan:

Barrett Highnoon