Buclizine (HCl)
Buclizine (HCl) is antihistaminic agent or antiemetic drug and used to prevent or treat nausea, vomiting and dizziness caused by motion sickness or middle ear infections, in the managment of allergic conditions, in pruritic skin disorders.
Primary Characteristics
It is of Synthetic origin and belongs to Piperazine.
It belongs to H1-antagonist pharmacological group on the basis of mechanism of action. It is also classified under Antiemetic/Antivertigo Agents .
Molecular Weight: 506 · Solubility in Water: slight soluble · Solubility in Alcohol: vey slightly soluble · Non-proprietary name: Buclizine (HCl).
Pharmacokinetics
Elimination: renal excretion is minor.
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Indications
Buclizine (HCl) is primarily indicated in conditions like Allergy, Anorexia, Migraine, Nausea and vomiting.
Contraindications
Buclizine (HCl) is contraindicated in conditions like Renal diseases.
Dosage
Buclizine (HCl)'s dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 50 mg | 50 mg | — | PO | 30 min before travel. |
| Paediatric Dosage (20kg) | ||||
| 0 – 0 | — | — | — | Not Recommended in this Age Group |
| Neonatal Dosage (3kg) | ||||
| 0 – 0 | — | — | Not recommended in this agegroup | |
Drug Interactions
None recorded.
Side Effects
Buclizine (HCl) is known to cause more or less tolerable side effects which are usually transient. These include Constipation , Depression, Diarrhea, Drowsiness, Dry mouth, Fatigue, Insomnia, Nausea, Nightmares, Palpitation, Transient gastric pain, Tremor, Urinary retention, Urinary RetentionX, Weight gain.
Warnings / Precautions
Available Brands
Storage Conditions
Drug Classification
- 1.3 — Anti-allergics (Antihistamines) and drugs used in anaphylaxis
- 2.17.2 — Antiemetics & antinauseants
- 3.27 — Vitamins, minerals, tonics, and other susbstances
Manufacturers
Manufacturers of Buclizine (HCl) in Pakistan: